[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

Research output: Contribution to journalArticle

Abstract

[125I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (Ki=0.5nM; α7/α4β2=3414), has been synthesized in radiochemical yield of 33±6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1600Ci/mmol; 59.2MBq/μmol). [125I]Iodo-ASEM readily entered the brains of normal CD-1 mice and specifically and selectively labeled cerebral α7-nAChRs. [125I]iodo-ASEM is a new useful tool for studying α7-nAChR.

Original languageEnglish (US)
Pages (from-to)488-493
Number of pages6
JournalNuclear Medicine and Biology
Volume42
Issue number5
DOIs
StatePublished - May 1 2015

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Radioactivity
Brain

Keywords

  • Iodo-ASEM
  • Nicotinic acetylcholine receptor
  • SPECT
  • α7-nAChR

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR. / Gao, Yongjun; Mease, Ronnie; Olson, Thao T.; Kellar, Kenneth J.; Dannals, Robert F; Pomper, Martin Gilbert; Horti, Andrew.

In: Nuclear Medicine and Biology, Vol. 42, No. 5, 01.05.2015, p. 488-493.

Research output: Contribution to journalArticle

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AU - Kellar, Kenneth J.

AU - Dannals, Robert F

AU - Pomper, Martin Gilbert

AU - Horti, Andrew

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