[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

Yongjun Gao; Ronnie C. Mease; Thao T. Olson; Kenneth J. Kellar; Robert F. Dannals; Martin G. Pomper; Andrew G. Horti

doi:10.1016/j.nucmedbio.2014.12.008

[¹²⁵I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

Yongjun Gao, Ronnie C. Mease, Thao T. Olson, Kenneth J. Kellar, Robert F. Dannals, Martin G. Pomper, Andrew G. Horti

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

[¹²⁵I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (K_i=0.5nM; α7/α4β2=3414), has been synthesized in radiochemical yield of 33±6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1600Ci/mmol; 59.2MBq/μmol). [¹²⁵I]Iodo-ASEM readily entered the brains of normal CD-1 mice and specifically and selectively labeled cerebral α7-nAChRs. [¹²⁵I]iodo-ASEM is a new useful tool for studying α7-nAChR.

Original language	English (US)
Pages (from-to)	488-493
Number of pages	6
Journal	Nuclear Medicine and Biology
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.nucmedbio.2014.12.008
State	Published - May 1 2015

Keywords

Iodo-ASEM
Nicotinic acetylcholine receptor
SPECT
α7-nAChR

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/j.nucmedbio.2014.12.008

Cite this

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title = "[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR",

abstract = "[125I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (Ki=0.5nM; α7/α4β2=3414), has been synthesized in radiochemical yield of 33±6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1600Ci/mmol; 59.2MBq/μmol). [125I]Iodo-ASEM readily entered the brains of normal CD-1 mice and specifically and selectively labeled cerebral α7-nAChRs. [125I]iodo-ASEM is a new useful tool for studying α7-nAChR.",

keywords = "Iodo-ASEM, Nicotinic acetylcholine receptor, SPECT, α7-nAChR",

author = "Yongjun Gao and Mease, {Ronnie C.} and Olson, {Thao T.} and Kellar, {Kenneth J.} and Dannals, {Robert F.} and Pomper, {Martin G.} and Horti, {Andrew G.}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.nucmedbio.2014.12.008",

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AU - Gao, Yongjun

AU - Mease, Ronnie C.

AU - Olson, Thao T.

AU - Kellar, Kenneth J.

AU - Dannals, Robert F.

AU - Pomper, Martin G.

AU - Horti, Andrew G.

PY - 2015/5/1

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