125I‐β‐nerve growth factor binding is reduced in rat brain after stress exposure

G. Taglialatela, L. Angelucci, M. T. Ramacci, P. J. Foreman, J. R. Perez‐Polo

Research output: Contribution to journalArticle

Abstract

In the central nervous system (CNS), the presence of nerve growth factor (NGF) and its receptor, NGFR, in cholinergic neurons has been demonstrated. In this study we report that, after exposure to stress, there was a reduction in total binding of NGF in the hippocampus and basal forebrain of 3.5‐month‐old rats without significant changes in the frontal cortex or cerebellum. Chronic treatment with acetyl‐l‐carnitine (ALCAR), that prevents some age‐related impairments of CNS, for 1.5 months, decreased NGF binding in hippocampus and basal forebrain but abolished the stress‐related reduction of NGF binding observed in the hippocampus of untreated rats.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalJournal of neuroscience research
Volume25
Issue number3
DOIs
StatePublished - Mar 1990
Externally publishedYes

Keywords

  • CNS
  • NGF
  • acetyl‐l‐carnitine
  • aging
  • stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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