111In-8-hydroxyquinoline platelet labeling in dogs

V. L. Porter-Fink, Frederic E. Eckhauser

Research output: Contribution to journalArticle

Abstract

This report validates a technique of separating and labeling canine platelets using indium-111-labeled 8-hydroxyquinoline (111In-8-HQ). Platelet survival time in six normal dogs was 6.3 ± 0.7 (SD) days. Labeling efficiency using this technique was 51.8 ± 9.2% (SEM) and elution loss of 111In-8-HQ label from platelets was consistently less than 4%. 111In label offers no observable advantages over the more traditional 51Cr label for platelet survival studies. However, the high efficiency labeling and -γ-emission characteristics of 111In-8-HQ make it more suitable for non-invasive clot localization in patients with early pulmonary emboli and peripheral venous thrombi.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalJournal of Surgical Research
Volume31
Issue number1
DOIs
StatePublished - Jul 1981

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ASJC Scopus subject areas

  • Surgery

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