SUMO: A Multifaceted Modifier of Chromatin Structure and Function

Caelin Cubeñas-Potts; Michael J. Matunis

doi:10.1016/j.devcel.2012.11.020

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

Caelin Cubeñas-Potts, Michael J. Matunis

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Developmental Cell
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2012.11.020
State	Published - Jan 14 2013

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2012.11.020

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abstract = "A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.",

author = "Caelin Cube{\~n}as-Potts and Matunis, {Michael J.}",

note = "Funding Information: We are grateful to all of the members of the Matunis laboratory for helpful discussions and suggestions. We apologize to all colleagues whose studies we did not cite due to space limitations. C.C-P. is supported by the Johns Hopkins Bloomberg School of Public Health Sommer Scholars Program. Work in the Matunis laboratory is supported by grants from the National Institutes of Health.",

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N2 - A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

AB - A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

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SUMO: A Multifaceted Modifier of Chromatin Structure and Function

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