SUMO: A Multifaceted Modifier of Chromatin Structure and Function

Caelin Cubeñas-Potts, Michael J Matunis

Research output: Contribution to journalArticle

Abstract

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalDevelopmental Cell
Volume24
Issue number1
DOIs
StatePublished - Jan 14 2013

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Ubiquitin
Chromatin
Post Translational Protein Processing
Small Ubiquitin-Related Modifier Proteins
DNA Packaging
Gene expression
Histones
Packaging
Genes
Genome
Gene Expression
DNA
Proteins

ASJC Scopus subject areas

  • Developmental Biology

Cite this

SUMO : A Multifaceted Modifier of Chromatin Structure and Function. / Cubeñas-Potts, Caelin; Matunis, Michael J.

In: Developmental Cell, Vol. 24, No. 1, 14.01.2013, p. 1-12.

Research output: Contribution to journalArticle

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