SUMO: A Multifaceted Modifier of Chromatin Structure and Function

Caelin Cubeñas-Potts, Michael J. Matunis

Research output: Contribution to journalReview articlepeer-review

Abstract

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalDevelopmental Cell
Volume24
Issue number1
DOIs
StatePublished - Jan 14 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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