Abstract
A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Developmental Cell |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 14 2013 |
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ASJC Scopus subject areas
- Developmental Biology
Cite this
SUMO : A Multifaceted Modifier of Chromatin Structure and Function. / Cubeñas-Potts, Caelin; Matunis, Michael J.
In: Developmental Cell, Vol. 24, No. 1, 14.01.2013, p. 1-12.Research output: Contribution to journal › Article
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TY - JOUR
T1 - SUMO
T2 - A Multifaceted Modifier of Chromatin Structure and Function
AU - Cubeñas-Potts, Caelin
AU - Matunis, Michael J
PY - 2013/1/14
Y1 - 2013/1/14
N2 - A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
AB - A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
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UR - http://www.scopus.com/inward/citedby.url?scp=84872413578&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2012.11.020
DO - 10.1016/j.devcel.2012.11.020
M3 - Article
C2 - 23328396
AN - SCOPUS:84872413578
VL - 24
SP - 1
EP - 12
JO - Developmental Cell
JF - Developmental Cell
SN - 1534-5807
IS - 1
ER -