Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation

Steven J. Chadban, Curie Ahn, David A. Axelrod, Bethany J. Foster, Bertram L. Kasiske, Vijah Kher, Deepali Kumar, Rainer Oberbauer, Julio Pascual, Helen L. Pilmore, James R. Rodrigue, Dorry L. Segev, Neil S. Sheerin, Kathryn J. Tinckam, Germaine Wong, Ethan M. Balk, Craig E. Gordon, Amy Earley, Valerie Rofeberg, Gregory A. Knoll

Research output: Contribution to journalReview articlepeer-review

Abstract

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transplantation such as adherence, tobacco use, diabetes, obesity, perioperative issues, causes of kidney failure, infections, malignancy, pulmonary disease, cardiac and peripheral arterial disease, neurologic disease, gastrointestinal and liver disease, hematologic disease, and bone and mineral disorder are also addressed. This guideline provides recommendations for evaluation of individual aspects of a candidate's profile such that each risk factor and comorbidity are considered separately. The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach. Guideline recommendations are primarily based on systematic reviews of relevant studies and our assessment of the quality of that evidence. The strengths of recommendations are provided in the full report. Limitations of the evidence are discussed with differences from previous guidelines noted and suggestions for future research are also provided.

Original languageEnglish (US)
Pages (from-to)708-714
Number of pages7
JournalTransplantation
Volume104
Issue number4
DOIs
StatePublished - Apr 1 2020

Keywords

  • CKD-MBD
  • HLA
  • KDIGO
  • adherence
  • albuminuria
  • bone and mineral metabolism
  • cancer
  • cardiac disease
  • clinical practice guideline
  • compatibility
  • diabetes mellitus
  • end-stage kidney disease
  • evidence-based recommendation
  • gastrointestinal disease
  • genetic kidney disease
  • hematological disorders
  • hematuria
  • immunological assessment
  • infectious diseases
  • kidney transplantation
  • liver disease
  • malignancy
  • mineral and bone disorder
  • neurologic disease
  • obesity
  • pediatric
  • perioperative
  • peripheral arterial disease
  • psychosocial
  • pulmonary disease
  • systematic review
  • tobacco

ASJC Scopus subject areas

  • Transplantation

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