Sulindac suppresses tumorigenesis in the Min mouse

Yasmin Beazer-Barclay; Daniel B. Levy; Amy R. Moser; William F. Dove; Stanley R. Hamilton; Bert Vogelstein; Kenneth W. Kinzler

doi:10.1093/carcin/17.8.1757

Sulindac suppresses tumorigenesis in the Min mouse

Yasmin Beazer-Barclay, Daniel B. Levy, Amy R. Moser, William F. Dove, Stanley R. Hamilton, Bert Vogelstein, Kenneth W. Kinzler

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load. The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.

Original language	English (US)
Pages (from-to)	1757-1760
Number of pages	4
Journal	Carcinogenesis
Volume	17
Issue number	8
DOIs	https://doi.org/10.1093/carcin/17.8.1757
State	Published - Aug 1996

ASJC Scopus subject areas

Cancer Research

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title = "Sulindac suppresses tumorigenesis in the Min mouse",

abstract = "The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load. The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.",

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AU - Beazer-Barclay, Yasmin

AU - Levy, Daniel B.

AU - Moser, Amy R.

AU - Dove, William F.

AU - Hamilton, Stanley R.

AU - Vogelstein, Bert

AU - Kinzler, Kenneth W.

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AB - The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load. The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.

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Sulindac suppresses tumorigenesis in the Min mouse

Abstract

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