Sulindac suppresses tumorigenesis in the Min mouse

Yasmin Beazer-Barclay, Daniel B. Levy, Amy R. Moser, William F. Dove, Stanley R. Hamilton, Bert Vogelstein, Kenneth W Kinzler

Research output: Contribution to journalArticle

Abstract

The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load. The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.

Original languageEnglish (US)
Pages (from-to)1757-1760
Number of pages4
JournalCarcinogenesis
Volume17
Issue number8
StatePublished - Aug 1996

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Sulindac
Carcinogenesis
Adenomatous Polyposis Coli
Tumor Burden
Drinking Water
Diet

ASJC Scopus subject areas

  • Cancer Research

Cite this

Beazer-Barclay, Y., Levy, D. B., Moser, A. R., Dove, W. F., Hamilton, S. R., Vogelstein, B., & Kinzler, K. W. (1996). Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis, 17(8), 1757-1760.

Sulindac suppresses tumorigenesis in the Min mouse. / Beazer-Barclay, Yasmin; Levy, Daniel B.; Moser, Amy R.; Dove, William F.; Hamilton, Stanley R.; Vogelstein, Bert; Kinzler, Kenneth W.

In: Carcinogenesis, Vol. 17, No. 8, 08.1996, p. 1757-1760.

Research output: Contribution to journalArticle

Beazer-Barclay, Y, Levy, DB, Moser, AR, Dove, WF, Hamilton, SR, Vogelstein, B & Kinzler, KW 1996, 'Sulindac suppresses tumorigenesis in the Min mouse', Carcinogenesis, vol. 17, no. 8, pp. 1757-1760.
Beazer-Barclay Y, Levy DB, Moser AR, Dove WF, Hamilton SR, Vogelstein B et al. Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis. 1996 Aug;17(8):1757-1760.
Beazer-Barclay, Yasmin ; Levy, Daniel B. ; Moser, Amy R. ; Dove, William F. ; Hamilton, Stanley R. ; Vogelstein, Bert ; Kinzler, Kenneth W. / Sulindac suppresses tumorigenesis in the Min mouse. In: Carcinogenesis. 1996 ; Vol. 17, No. 8. pp. 1757-1760.
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