@article{9cf2a79964ba4b37b37cd3f15a7eefd9,
title = "Sulfhydration mediates neuroprotective actions of parkin",
abstract = "Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson's disease are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic Parkinson's disease. Here we demonstrate that physiologic modification of parkin by hydrogen sulfide, termed sulfhydration, enhances its catalytic activity. Sulfhydration sites are identified by mass spectrometry analysis and are investigated by site-directed mutagenesis. Parkin sulfhydration is markedly depleted in the brains of patients with Parkinson's disease, suggesting that this loss may be pathologic. This implies that hydrogen sulfide donors may be therapeutic.",
author = "Vandiver, {M. Scott} and Paul, {Bindu D.} and Risheng Xu and Senthilkumar Karuppagounder and Feng Rao and Snowman, {Adele M.} and {Seok Ko}, Han and {Il Lee}, Yun and Dawson, {Valina L.} and Dawson, {Ted M.} and Nilkantha Sen and Snyder, {Solomon H.}",
note = "Funding Information: This work was supported by the National Institutes of Health Medical Scientist Training Program Award (T32 GM007309), the US Public Health Service grant (MH018501) and the National Institutes of Health grant (NS38377). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. We acknowledge Dr. Bob Cole and Lauren Hitt (Johns Hopkins University Mass Spectrometry Core) in identifying parkin sulfhydration sites. We acknowledge the joint participation by the Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with The Johns Hopkins Hospital and the Johns Hopkins University School of Medicine, and the Foundation{\textquoteright}s Parkinson{\textquoteright}s Disease Program No. M-1.",
year = "2013",
doi = "10.1038/ncomms2623",
language = "English (US)",
volume = "4",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}