TY - JOUR
T1 - Suicidal ideation and planning among Mexican adolescents are associated with depression polygenic risk scores
AU - Martinez-Levy, Gabriela A.
AU - Campos, Adrian I.
AU - Rabinowitz, Jill A.
AU - García-Marín, Luis M.
AU - Benjet, Corina
AU - Méndez, Enrique
AU - Rentería, Miguel E.
AU - Cruz-Fuentes, Carlos S.
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2021/12
Y1 - 2021/12
N2 - Suicide is a major public health problem in Mexico and around the world. Genetic predisposition for major depressive disorder (MDD) has been associated with increased risk for suicidal behaviors (SB) in populations of European ancestry (EA). Here, we examine whether MDD polygenic risk scores (MDD PRS), derived from a genome-wide association study involving EA individuals, predict SB, including ideation, planning, and attempt, among Mexican youth using a longitudinal design. At baseline, participants (N = 1,128, 12–17 years, 55% women) were interviewed and genotyped as part of a general population survey on adolescent mental health. Eight years later, they were recontacted for a follow up visit (N = 437, 20–25 years, 63% women). At both assessments, individuals reported on their engagement in SB within the past year. MDD PRS were significantly positively associated with SB, particularly suicide ideation and planning during adolescence, accounting for ~4–5% of the variance in these outcomes. In contrast, associations between MDD PRS and SB during young adulthood did not reach statistical significance. Our results suggest that increased genetic liability for depression increased risk for SB, particularly during adolescence, expanding our knowledge of the genetic underpinnings of SB.
AB - Suicide is a major public health problem in Mexico and around the world. Genetic predisposition for major depressive disorder (MDD) has been associated with increased risk for suicidal behaviors (SB) in populations of European ancestry (EA). Here, we examine whether MDD polygenic risk scores (MDD PRS), derived from a genome-wide association study involving EA individuals, predict SB, including ideation, planning, and attempt, among Mexican youth using a longitudinal design. At baseline, participants (N = 1,128, 12–17 years, 55% women) were interviewed and genotyped as part of a general population survey on adolescent mental health. Eight years later, they were recontacted for a follow up visit (N = 437, 20–25 years, 63% women). At both assessments, individuals reported on their engagement in SB within the past year. MDD PRS were significantly positively associated with SB, particularly suicide ideation and planning during adolescence, accounting for ~4–5% of the variance in these outcomes. In contrast, associations between MDD PRS and SB during young adulthood did not reach statistical significance. Our results suggest that increased genetic liability for depression increased risk for SB, particularly during adolescence, expanding our knowledge of the genetic underpinnings of SB.
KW - Mexican youth
KW - depression
KW - genetics
KW - polygenic risk scores
KW - suicidal behavior
UR - http://www.scopus.com/inward/record.url?scp=85108839274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108839274&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.32864
DO - 10.1002/ajmg.b.32864
M3 - Article
C2 - 34173322
AN - SCOPUS:85108839274
SN - 1552-4841
VL - 186
SP - 476
EP - 484
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 8
ER -