Sugar Makes Fat by Talking to SCAP

Research output: Contribution to journalArticle

Abstract

Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.

Original languageEnglish (US)
Pages (from-to)548-549
Number of pages2
JournalCancer Cell
Volume28
Issue number5
DOIs
Publication statusPublished - Nov 9 2015

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ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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