TY - JOUR
T1 - Sugar Makes Fat by Talking to SCAP
AU - Shao, Wei
AU - Espenshade, Peter J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/11/9
Y1 - 2015/11/9
N2 - Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.
AB - Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.
UR - http://www.scopus.com/inward/record.url?scp=84946560554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946560554&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2015.10.011
DO - 10.1016/j.ccell.2015.10.011
M3 - Short survey
C2 - 26555169
AN - SCOPUS:84946560554
SN - 1535-6108
VL - 28
SP - 548
EP - 549
JO - Cancer cell
JF - Cancer cell
IS - 5
ER -