SU‐E‐T‐670

Using Overlap Volume Histogram Analysis of a Prior Plan Dataset to Generate Clinically Acceptable Plans for CyberKnife Robotic Radiosurgery Treatment of Localized Prostate Cancer

B. wu, D. Pang, J. Gatti, S. Lei, S. Colin, Todd McNutt, T. Kole, S. p. Collins, A. Dritschilo

Research output: Contribution to journalArticle

Abstract

Purpose: CyberKnife offers the potential benefits of non‐isocentric, non‐coplanar treatment delivery. However, its planning is a laborious manual, trial‐and‐error process. This study is to investigate whether an overlap volume histogram (OVH)‐driven planning approach can produce clinically acceptable plans for treatment of localized prostate cancer. Methods: It is assumed that given consistent target coverage, patients with a relevant target‐organ spatial relationship should have similar organ sparing. The OVH is used to characterize the 3‐D spatial relationship between an organ and a target. A database containing the OVH and DVH of prior plans is built to serve as an external reference. During the initial planning, the OVH is used to search through the database to find a prior patient group whose target‐organ relationship is related to that of a new patient. The planning objectives for the new patient are then estimated from the group and input into the CyberKnife TPS for optimization. To demonstrate the effectiveness of the method, the plans of 12 prostate patients (prescription: 36.25Gy in 5 fractions) are generated by the OVH approach and compared to the corresponding clinical plans using the in‐house dosimetric guidelines. Results: Physicians confirm that OVH plans are clinically acceptable. OVH plans: on average, Vcc(37Gy) and V(18.12Gy) to the bladder decrease 1cc and 6% (p<0.05); Vcc(36Gy) and V(18.12Gy) to the rectum decrease 0.02cc and 4.3% (p=0.3); Vcc(40Gy) to the prostatic urethra decreases 0.08cc (p=0.01); V(14.5Gy) to the femur heads decreases 0.58% (p=0.01). V(37Gy) to the membranous urethra increases from 23.1% to 24.5% (p=0.75); V(29.5Gy) to the penile bulb increases from 5.5% to 10.7% (p=0.35); V(36.25Gy) to PTV increases 0.2% (p=0.4); the estimated delivery time deceases 3.5 minutes (p=0.01). Conclusion: With respect to planner‐created clinical plans, this approach offers an alternative way to generate clinically acceptable plans. It advances the possibility of automated CyberKnife planning. C. Sims, employed by Accuray, Inc;S.P Collins, Accuray clinical consultant.

Original languageEnglish (US)
Pages (from-to)360
Number of pages1
JournalMedical Physics
Volume40
Issue number6
DOIs
StatePublished - 2013

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Radiosurgery
Robotics
Prostatic Neoplasms
Urethra
Femur Head
Databases
Therapeutics
Consultants
Rectum
Prescriptions
Prostate
Urinary Bladder
Datasets
Guidelines
Physicians

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

SU‐E‐T‐670 : Using Overlap Volume Histogram Analysis of a Prior Plan Dataset to Generate Clinically Acceptable Plans for CyberKnife Robotic Radiosurgery Treatment of Localized Prostate Cancer. / wu, B.; Pang, D.; Gatti, J.; Lei, S.; Colin, S.; McNutt, Todd; Kole, T.; Collins, S. p.; Dritschilo, A.

In: Medical Physics, Vol. 40, No. 6, 2013, p. 360.

Research output: Contribution to journalArticle

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title = "SU‐E‐T‐670: Using Overlap Volume Histogram Analysis of a Prior Plan Dataset to Generate Clinically Acceptable Plans for CyberKnife Robotic Radiosurgery Treatment of Localized Prostate Cancer",
abstract = "Purpose: CyberKnife offers the potential benefits of non‐isocentric, non‐coplanar treatment delivery. However, its planning is a laborious manual, trial‐and‐error process. This study is to investigate whether an overlap volume histogram (OVH)‐driven planning approach can produce clinically acceptable plans for treatment of localized prostate cancer. Methods: It is assumed that given consistent target coverage, patients with a relevant target‐organ spatial relationship should have similar organ sparing. The OVH is used to characterize the 3‐D spatial relationship between an organ and a target. A database containing the OVH and DVH of prior plans is built to serve as an external reference. During the initial planning, the OVH is used to search through the database to find a prior patient group whose target‐organ relationship is related to that of a new patient. The planning objectives for the new patient are then estimated from the group and input into the CyberKnife TPS for optimization. To demonstrate the effectiveness of the method, the plans of 12 prostate patients (prescription: 36.25Gy in 5 fractions) are generated by the OVH approach and compared to the corresponding clinical plans using the in‐house dosimetric guidelines. Results: Physicians confirm that OVH plans are clinically acceptable. OVH plans: on average, Vcc(37Gy) and V(18.12Gy) to the bladder decrease 1cc and 6{\%} (p<0.05); Vcc(36Gy) and V(18.12Gy) to the rectum decrease 0.02cc and 4.3{\%} (p=0.3); Vcc(40Gy) to the prostatic urethra decreases 0.08cc (p=0.01); V(14.5Gy) to the femur heads decreases 0.58{\%} (p=0.01). V(37Gy) to the membranous urethra increases from 23.1{\%} to 24.5{\%} (p=0.75); V(29.5Gy) to the penile bulb increases from 5.5{\%} to 10.7{\%} (p=0.35); V(36.25Gy) to PTV increases 0.2{\%} (p=0.4); the estimated delivery time deceases 3.5 minutes (p=0.01). Conclusion: With respect to planner‐created clinical plans, this approach offers an alternative way to generate clinically acceptable plans. It advances the possibility of automated CyberKnife planning. C. Sims, employed by Accuray, Inc;S.P Collins, Accuray clinical consultant.",
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T2 - Using Overlap Volume Histogram Analysis of a Prior Plan Dataset to Generate Clinically Acceptable Plans for CyberKnife Robotic Radiosurgery Treatment of Localized Prostate Cancer

AU - wu, B.

AU - Pang, D.

AU - Gatti, J.

AU - Lei, S.

AU - Colin, S.

AU - McNutt, Todd

AU - Kole, T.

AU - Collins, S. p.

AU - Dritschilo, A.

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N2 - Purpose: CyberKnife offers the potential benefits of non‐isocentric, non‐coplanar treatment delivery. However, its planning is a laborious manual, trial‐and‐error process. This study is to investigate whether an overlap volume histogram (OVH)‐driven planning approach can produce clinically acceptable plans for treatment of localized prostate cancer. Methods: It is assumed that given consistent target coverage, patients with a relevant target‐organ spatial relationship should have similar organ sparing. The OVH is used to characterize the 3‐D spatial relationship between an organ and a target. A database containing the OVH and DVH of prior plans is built to serve as an external reference. During the initial planning, the OVH is used to search through the database to find a prior patient group whose target‐organ relationship is related to that of a new patient. The planning objectives for the new patient are then estimated from the group and input into the CyberKnife TPS for optimization. To demonstrate the effectiveness of the method, the plans of 12 prostate patients (prescription: 36.25Gy in 5 fractions) are generated by the OVH approach and compared to the corresponding clinical plans using the in‐house dosimetric guidelines. Results: Physicians confirm that OVH plans are clinically acceptable. OVH plans: on average, Vcc(37Gy) and V(18.12Gy) to the bladder decrease 1cc and 6% (p<0.05); Vcc(36Gy) and V(18.12Gy) to the rectum decrease 0.02cc and 4.3% (p=0.3); Vcc(40Gy) to the prostatic urethra decreases 0.08cc (p=0.01); V(14.5Gy) to the femur heads decreases 0.58% (p=0.01). V(37Gy) to the membranous urethra increases from 23.1% to 24.5% (p=0.75); V(29.5Gy) to the penile bulb increases from 5.5% to 10.7% (p=0.35); V(36.25Gy) to PTV increases 0.2% (p=0.4); the estimated delivery time deceases 3.5 minutes (p=0.01). Conclusion: With respect to planner‐created clinical plans, this approach offers an alternative way to generate clinically acceptable plans. It advances the possibility of automated CyberKnife planning. C. Sims, employed by Accuray, Inc;S.P Collins, Accuray clinical consultant.

AB - Purpose: CyberKnife offers the potential benefits of non‐isocentric, non‐coplanar treatment delivery. However, its planning is a laborious manual, trial‐and‐error process. This study is to investigate whether an overlap volume histogram (OVH)‐driven planning approach can produce clinically acceptable plans for treatment of localized prostate cancer. Methods: It is assumed that given consistent target coverage, patients with a relevant target‐organ spatial relationship should have similar organ sparing. The OVH is used to characterize the 3‐D spatial relationship between an organ and a target. A database containing the OVH and DVH of prior plans is built to serve as an external reference. During the initial planning, the OVH is used to search through the database to find a prior patient group whose target‐organ relationship is related to that of a new patient. The planning objectives for the new patient are then estimated from the group and input into the CyberKnife TPS for optimization. To demonstrate the effectiveness of the method, the plans of 12 prostate patients (prescription: 36.25Gy in 5 fractions) are generated by the OVH approach and compared to the corresponding clinical plans using the in‐house dosimetric guidelines. Results: Physicians confirm that OVH plans are clinically acceptable. OVH plans: on average, Vcc(37Gy) and V(18.12Gy) to the bladder decrease 1cc and 6% (p<0.05); Vcc(36Gy) and V(18.12Gy) to the rectum decrease 0.02cc and 4.3% (p=0.3); Vcc(40Gy) to the prostatic urethra decreases 0.08cc (p=0.01); V(14.5Gy) to the femur heads decreases 0.58% (p=0.01). V(37Gy) to the membranous urethra increases from 23.1% to 24.5% (p=0.75); V(29.5Gy) to the penile bulb increases from 5.5% to 10.7% (p=0.35); V(36.25Gy) to PTV increases 0.2% (p=0.4); the estimated delivery time deceases 3.5 minutes (p=0.01). Conclusion: With respect to planner‐created clinical plans, this approach offers an alternative way to generate clinically acceptable plans. It advances the possibility of automated CyberKnife planning. C. Sims, employed by Accuray, Inc;S.P Collins, Accuray clinical consultant.

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