Sudden spasms following gradual lordosis - The stiff-person syndrome

Robin K. Wilson, Beth B. Murinson

Research output: Contribution to journalArticlepeer-review


Background: A 28-year-old woman presented to hospital after an episode of severe lower back spasms that occurred during a stressful family gathering. She had a history of progressive difficulty bending forward and increasing lumbar lordosis. Investigations: Physical examination, spine MRI scan, abdominal and pelvic ultrasound, electromyogram, nerve conduction studies, cerebrospinal fluid analysis, breast examination, Pap smear, transabdominal and endovaginal ultrasound. Diagnosis: Stiff-person syndrome with high titer of antibodies against glutamic acid decarboxylase. Treatment: Benzodiazepines and intravenous immunoglobulins.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalNature Clinical Practice Neurology
Issue number8
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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