Sudden death related cardiomyopathies - Hypertrophic cardiomyopathy

Zackary D. Goff, Hugh Calkins

Research output: Contribution to journalReview articlepeer-review


Hypertrophic cardiomyopathy (HCM)is a form of inherited cardiomyopathy. Most individuals with HCM experience minimal symptoms throughout their lifetime. However, those with HCM are at risk of ventricular arrhythmias and sudden cardiac death (SCD), the most feared complication of HCM. Implantable cardioverter defibrillator (ICD)implantation has played a large role in transforming this disease from one with an ominous prognosis to one with mortality rates that are on par with the general public. Since the early 2000s, balance between SCD prevention and unnecessary ICD placement has been sought, this is reflected in the evolution of SCD risk stratification models for patients with HCM. This review discusses key concepts pertaining to HCM, with emphasis on prevention of SCD, and summarizes and compares the recommendations for ICD implantation in current guidelines.

Original languageEnglish (US)
JournalProgress in Cardiovascular Diseases
StatePublished - Jan 1 2019


  • Cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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