TY - JOUR
T1 - Sucralfate causes malabsorption of L-thyroxine
AU - Sherman, Steven I.
AU - Tielens, Emile T.
AU - Ladenson, Paul W.
PY - 1994/6
Y1 - 1994/6
N2 - purpose: To determine if sucralfate causes malabsorption of L-thyroxine. patients and methods: Five healthy volunteers ingested L-thyroxine, 1,000 μg, administered orally (1) without sucralfate, (2) with sucralfate, 1 g, and (3) 8 hours after sucralfate, 2 g. The amount of L- thyroxine absorbed was calculated from the peak increase in serum T4 levels within 6 hours of hormone ingestion multiplied by the volume of distribution for the hormone. results: Peak absorption of L-thyroxine in the absence of sucralfate was 796 μg (95% confidence interval (CI): 515 - 1,074 μg). Coadministration of sucralfate, 1 g, with L- thyroxine reduced thyroid hormone absorption to 225 μg (95% Cl: 151 - 299 μg) (P = 0.0029 compared with control). Peak hormone absorption was delayed 2 hours by simultaneous sucralfate ingestion. Separation of administered L-thyroxine and sucralfate doses by 8 hours returned hormone absorption to control values. Maximum T3 levels did not differ, regardless of drug regimen, but suppression of thyroid-stimulating hormone (TSH) by L- thyroxine was reduced by coadministration of sucralfate. conclusions: Sucralfate causes malabsorption of L-thyroxine, presumably by intraluminal binding of hormone.
AB - purpose: To determine if sucralfate causes malabsorption of L-thyroxine. patients and methods: Five healthy volunteers ingested L-thyroxine, 1,000 μg, administered orally (1) without sucralfate, (2) with sucralfate, 1 g, and (3) 8 hours after sucralfate, 2 g. The amount of L- thyroxine absorbed was calculated from the peak increase in serum T4 levels within 6 hours of hormone ingestion multiplied by the volume of distribution for the hormone. results: Peak absorption of L-thyroxine in the absence of sucralfate was 796 μg (95% confidence interval (CI): 515 - 1,074 μg). Coadministration of sucralfate, 1 g, with L- thyroxine reduced thyroid hormone absorption to 225 μg (95% Cl: 151 - 299 μg) (P = 0.0029 compared with control). Peak hormone absorption was delayed 2 hours by simultaneous sucralfate ingestion. Separation of administered L-thyroxine and sucralfate doses by 8 hours returned hormone absorption to control values. Maximum T3 levels did not differ, regardless of drug regimen, but suppression of thyroid-stimulating hormone (TSH) by L- thyroxine was reduced by coadministration of sucralfate. conclusions: Sucralfate causes malabsorption of L-thyroxine, presumably by intraluminal binding of hormone.
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U2 - 10.1016/0002-9343(94)90093-0
DO - 10.1016/0002-9343(94)90093-0
M3 - Article
C2 - 8017451
AN - SCOPUS:0028288004
SN - 0002-9343
VL - 96
SP - 531
EP - 535
JO - The American journal of medicine
JF - The American journal of medicine
IS - 6
ER -