Successful treatment of single infected calciphylaxis lesion with intralesional injection of sodium thiosulfate at high concentration

Bara Zuhaili, Khalid Al-Talib

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Calciphylaxis is a very complicated disease that usually presents in patients with end-stage renal disease (ESRD). Treatment for calciphylaxis is not well standardized and typically involves a multidisciplinary approach. One of the common medications used in calciphylaxis treatment is sodium thiosulfate (STS). However, its intravenous injection is associated with multiple side effects. Case Report. The authors present a case report of an intralesional injection of STS followed by a literature review of the common treatment modalities and possible further use of intralesional injections. A 51-year-old man with ESRD on peritoneal dialysis presented with a right calf biopsy-proven calciphylaxis lesion measuring 3.1 cm x 3.9 cm. About the same time, he had Pseudomonas-associated peritoneal catheter eritonitis. The calciphylaxis lesion was treated with bimonthly intralesional injections of STS. The lesion had a complete resolution b week 9. Conclusions. The authors believe a higher local concentration of STS leading to a faster resolution and requiring less frequent injections needs to be further evaluated. Following additional studies, they also propose a greater use of intralesional STS injections in a select set of patients in the future.

Original languageEnglish (US)
Pages (from-to)E54-E57
JournalWounds
Volume31
Issue number8
StatePublished - Jan 1 2019

Keywords

  • Calciphylaxis
  • End-stage renal disease
  • ESRD
  • Infection
  • Lesion
  • Sodium thiosulfate

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

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