Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H

Mwe Chao Mwe, John E. Levine, James L. Ferrara, Laura Cooling, Kenneth R. Cooke, Raymond J. Hutchinson, Gregory A. Yanik

Research output: Contribution to journalArticlepeer-review

Abstract

Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.

Original languageEnglish (US)
Pages (from-to)917-919
Number of pages3
JournalPediatric Blood and Cancer
Volume50
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Campath-1H
  • Cord blood transplantation
  • Evans syndrome
  • Immune hemolytic anemia
  • X-linked adrenoleukodystrophy (ALD)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H'. Together they form a unique fingerprint.

Cite this