Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H

Mwe Chao Mwe; John E. Levine; James L. Ferrara; Laura Cooling; Kenneth R. Cooke; Raymond J. Hutchinson; Gregory A. Yanik

doi:10.1002/pbc.21187

Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H

Mwe Chao Mwe, John E. Levine, James L. Ferrara, Laura Cooling, Kenneth R. Cooke, Raymond J. Hutchinson, Gregory A. Yanik

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.

Original language	English (US)
Pages (from-to)	917-919
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	50
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21187
State	Published - Apr 2008
Externally published	Yes

Keywords

Campath-1H
Cord blood transplantation
Evans syndrome
Immune hemolytic anemia
X-linked adrenoleukodystrophy (ALD)

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.21187

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title = "Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H",

abstract = "Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.",

keywords = "Campath-1H, Cord blood transplantation, Evans syndrome, Immune hemolytic anemia, X-linked adrenoleukodystrophy (ALD)",

author = "Mwe, {Mwe Chao} and Levine, {John E.} and Ferrara, {James L.} and Laura Cooling and Cooke, {Kenneth R.} and Hutchinson, {Raymond J.} and Yanik, {Gregory A.}",

year = "2008",

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AU - Levine, John E.

AU - Ferrara, James L.

AU - Cooling, Laura

AU - Cooke, Kenneth R.

AU - Hutchinson, Raymond J.

AU - Yanik, Gregory A.

PY - 2008/4

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N2 - Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.

AB - Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.

KW - Campath-1H

KW - Cord blood transplantation

KW - Evans syndrome

KW - Immune hemolytic anemia

KW - X-linked adrenoleukodystrophy (ALD)

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Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with campath-1H

Abstract

Keywords

ASJC Scopus subject areas

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