Successful Treatment of Human Genital Herpes Infections With 2-Deoxy-D-glucose

Herbert A. Blough, Robert L. Giuntoli

Research output: Contribution to journalArticle

Abstract

Thirty-six women with genital herpes infections (proved by virological or cytological means) were treated in a double-blind placebo-controlled study with the glucose analogue 2-deoxy-D-glucose for a three-week period. In initial mucocutaneous cases, 89% were cured, with two recurrences after 24 months; in the case of recurrent or secondary infections, 90% had a notable improvement manifested by no or less-frequent recurrences, fewer lesions, or shortened duration of symptoms. In initial infections, discomfort cleared within 12 to 72 hours of therapy; 90% of the patients were asymptomatic within four days. In both cases, virus shedding was notably reduced by 2-deoxy-D-glucose. Concomitant controls treated with placebos failed to respond within this time frame. The use of 2-deoxy-D-glucose provides a simple and unique approach to the treatment of genital herpesvirus infections. (JAMA 241:2798-2801, 1979).

Original languageEnglish (US)
Pages (from-to)2798-2801
Number of pages4
JournalJournal of the American Medical Association
Volume241
Issue number26
DOIs
StatePublished - Jun 29 1979
Externally publishedYes

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Herpes Genitalis
Deoxyglucose
Infection
Placebos
Virus Shedding
Herpesviridae Infections
Recurrence
Coinfection
Therapeutics
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Successful Treatment of Human Genital Herpes Infections With 2-Deoxy-D-glucose. / Blough, Herbert A.; Giuntoli, Robert L.

In: Journal of the American Medical Association, Vol. 241, No. 26, 29.06.1979, p. 2798-2801.

Research output: Contribution to journalArticle

Blough, Herbert A. ; Giuntoli, Robert L. / Successful Treatment of Human Genital Herpes Infections With 2-Deoxy-D-glucose. In: Journal of the American Medical Association. 1979 ; Vol. 241, No. 26. pp. 2798-2801.
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