@article{16f241836e2c469c83a91ca27251ea45,
title = "SUCCESSFUL TREATMENT OF HOMOZYGOUS PROTEIN C DEFICIENCY BY HEPATIC TRANSPLANTATION",
abstract = "A child with homozygous protein C deficiency was treated at age 20 months by orthotopic hepatic transplantation. Postoperatively there was complete reconstitution of protein C activity and resolution of the thrombotic condition.",
author = "Casella, {James F.} and Bontempo, {Francis A.} and Howard Markel and Lewis, {Jessica H.} and Zitelli, {Basil J.} and Starzl, {Thomas E.}",
note = "Funding Information: The study was funded by the Naval Medical Research and Development Funding Information: most successful, either through carrier detection in high-risk populations or through gene therapy. We thank Dr Richard A. Marlar and Dr Robert R. Montgomery (Blood Center of Southeastern Wisconsin) for performing the initial protein C determinations. They and Dr William H. Zinkham and Dr George J. Dover (Johns Hopkins School of Medicine) and Dr William Hathaway (University of Colorado School of Medicine) provided helpful comments. This work was supported in part by NIH NHLBI Clinical Investigator Award HL 01341 to J. F. C. and AM 29961 to T. E. S. Correspondence should be addressed to J. F. C., Room 201, Brady Building, Johns Hopkins Hospital, Baltimore, MD 21205, USA.",
year = "1988",
month = feb,
day = "27",
doi = "10.1016/S0140-6736(88)91231-7",
language = "English (US)",
volume = "331",
pages = "435--438",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8583",
}