Successful treatment of coccidioidal meningitis with voriconazole

Karoll J. Cortez, Thomas J. Walsh, John E. Bennett

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


A previously healthy 47-year-old man with coccidioidal meningitis had fluconazole treatment failure and developed severe symptoms, multiple cranial nerve palsies, and brainstem inflammation visible on magnetic resonance imaging (MRI). High-dose voriconazole therapy resulted in gradual resolution of almost all signs and symptoms, normalization of cerebrospinal fluid, and clearing of brain-stem edema seen on MRI. The patient had photosensitivity after 10 weeks of treatment, but this improved when the voriconazole dose was lowered. Continuous voriconazole therapy kept coccidioidal meningitis in complete remission in this patient for >2 years.

Original languageEnglish (US)
Pages (from-to)1619-1622
Number of pages4
JournalClinical Infectious Diseases
Issue number12
StatePublished - Jun 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Successful treatment of coccidioidal meningitis with voriconazole'. Together they form a unique fingerprint.

Cite this