Successful treatment of coccidioidal meningitis with voriconazole

Karoll J. Cortez, Thomas J. Walsh, John E. Bennett

Research output: Contribution to journalArticle

Abstract

A previously healthy 47-year-old man with coccidioidal meningitis had fluconazole treatment failure and developed severe symptoms, multiple cranial nerve palsies, and brainstem inflammation visible on magnetic resonance imaging (MRI). High-dose voriconazole therapy resulted in gradual resolution of almost all signs and symptoms, normalization of cerebrospinal fluid, and clearing of brain-stem edema seen on MRI. The patient had photosensitivity after 10 weeks of treatment, but this improved when the voriconazole dose was lowered. Continuous voriconazole therapy kept coccidioidal meningitis in complete remission in this patient for >2 years.

Original languageEnglish (US)
Pages (from-to)1619-1622
Number of pages4
JournalClinical Infectious Diseases
Volume36
Issue number12
DOIs
StatePublished - Jun 15 2003
Externally publishedYes

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Meningitis
Brain Stem
Magnetic Resonance Imaging
Cranial Nerve Diseases
Fluconazole
Brain Edema
Treatment Failure
Signs and Symptoms
Cerebrospinal Fluid
Therapeutics
Inflammation
Voriconazole

ASJC Scopus subject areas

  • Immunology

Cite this

Successful treatment of coccidioidal meningitis with voriconazole. / Cortez, Karoll J.; Walsh, Thomas J.; Bennett, John E.

In: Clinical Infectious Diseases, Vol. 36, No. 12, 15.06.2003, p. 1619-1622.

Research output: Contribution to journalArticle

Cortez, Karoll J. ; Walsh, Thomas J. ; Bennett, John E. / Successful treatment of coccidioidal meningitis with voriconazole. In: Clinical Infectious Diseases. 2003 ; Vol. 36, No. 12. pp. 1619-1622.
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