Successful treatment of calciphylaxis with intravenous sodium thiosulfate

Jeffrey S. Cicone, John B. Petronis, Carmen D. Embert, David A. Spector

Research output: Contribution to journalArticlepeer-review


Calciphylaxis is a dreaded complication of renal failure characterized by nodular subcutaneous calcification and painful tissue necrosis often leading to ulceration, secondary infection, and high mortality rates. The case of a woman receiving continuous ambulatory peritoneal dialysis who had a typical clinical presentation of calciphylaxis confirmed by x-ray and technetium scan findings is described. After nonresponse to conventional therapy, treatment with Intravenous sodium thiosulfate 3 times weekly was begun, and she had rapid and dramatic relief of signs and symptoms and improvement of technetium scans. Prolonged treatment was well tolerated without serious side effects and accompanied by continued clinical improvement.

Original languageEnglish (US)
Pages (from-to)1104-1108
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number6
StatePublished - Jun 2004


  • Calciphylaxis
  • Peritoneal dialysis (PD)
  • Sodium thiosulfate
  • Technetium bone scan

ASJC Scopus subject areas

  • Nephrology


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