Successful treatment of a prolactin-producing pituitary macroadenoma with intravaginal bromocriptine mesylate: A novel approach to intolerance of oral therapy

Eugene Katz, Horst F. Schran, Eli Y. Adashi

Research output: Contribution to journalArticle

Abstract

A 37-year-old woman with a symptomatic 18-mm prolactinsecreting pituitary adenoma could not be managed with oral bromocriptine mesylate because of unacceptable gastrointestinal side effects. However, when given the medication intravaginally, the patient was successfully treated as assessed by evident tumor shrinkage and diminished secretory activity. Serum bromocriptine levels were approximately six to eight times higher than those reported after oral administration. The vaginal route may help reduce some of the adverse effects of bromocriptine mesylate experienced during oral administration and may possibly allow lowering of the overall effective dose by avoiding first liver passage.

Original languageEnglish (US)
Pages (from-to)517-520
Number of pages4
JournalObstetrics and gynecology
Volume73
Issue number3
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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