Successful three-way kidney paired donation with cross-country live donor allograft transport

R. A. Montgomery, S. Katznelson, W. I. Bry, A. A. Zachary, J. Houp, J. M. Hiller, S. Shridharani, D. John, A. L. Singer, D. L. Segev

Research output: Contribution to journalArticle

Abstract

Providing transplantation opportunities for patients with incompatible live donors through kidney paired donation (KPD) is seen as one of the important strategies for easing the crisis in organ availability. It has been estimated that an additional 1000 - 2000 transplants per year could be accomplished if a national KPD program were implemented in the United States. While most of these transplants could be arranged within the participants' local or regional area, patients with hard-to-match blood types or broad HLA sensitization would benefit from matching across larger geographic areas. In this case, either patients or organs would need to travel in order to obtain maximum benefit from a national program. In this study, we describe how a triple KPD enabled a highly sensitized patient (PRA 96%) to receive a well-matched kidney from a live donor on the opposite coast. The kidney was removed in San Francisco and transported to Baltimore where it was reperfused 8 h later. The patient had prompt function and 1 year later has a serum creatinine of 1.1 mg/dl. This case provides a blueprint for solving some of the complexities that are inherent in the implementation of a national KPD program in a large country like the United States.

Original languageEnglish (US)
Pages (from-to)2163-2168
Number of pages6
JournalAmerican Journal of Transplantation
Volume8
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • ABO incompatible
  • Incompatible kidney transplants
  • Kidney paired donation
  • Paired kidney exchange
  • Positive crossmatch
  • Shipping live donor kidneys
  • Triple swap

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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