Successful renal transplantation of deceased donor kidneys with 100% glomerular fibrin thrombi & acute renal failure due to disseminated intravascular coagulation

Kevin C. Soares, Lois J. Arend, Bonnie Lonze, Niraj M. Desai, Nada Alachkar, Fizza Naqvi, Robert A. Montgomery

Research output: Contribution to journalArticlepeer-review

Abstract

Background.Disseminated intravascular coagulation (DIC)-positive kidneys have historically been turned down for fear of poor outcomes. Higher severity injuries, which are prone to DIC, are typically seen in younger, otherwise healthy potential donors. The continued kidney allograft shortage has generated interest in the use of these DIC-positive grafts. There have been some reports of acceptable outcomes of renal transplantation using kidneys from donors with DIC. There aremultiple clinical series demonstrating good outcomes from DIC-positive kidneys when the extent of glomeruli containing fibrin thrombi is less than 50% and donor renal function is preserved. These grafts are frequently associated with a period of delayed graft function.Methods.We report 2 transplants with kidneys from brain dead donors with known DIC. Results. Both donors had renal failure and pretransplant renal biopsies showing 100% of the glomeruli containing fibrin thrombi. The recipients experienced delayed graft function requiring hemodialysis which was discontinued on postoperative days 18 and 39 for cases 1 and 2, respectively. Both patients are now over 14months posttransplant with stable allograft function. Conclusions. Until clearer organ selection criteria are established, caution should be exercised when considering the use of kidneys with a similar phenotype and allocation decisions made by a multidisciplinary transplant team on a case-by-case basis.

Original languageEnglish (US)
Pages (from-to)1134-1138
Number of pages5
JournalTransplantation
Volume101
Issue number6
DOIs
StatePublished - Jun 2017

ASJC Scopus subject areas

  • Transplantation

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