Successful prevention and treatment of babesiosis with atovaquone

Walter T. Hughes, Helieh S. Oz

Research output: Contribution to journalArticlepeer-review

Abstract

Atovaquone was evaluated for the prevention and treatment of babesiosis in hamsters. When atovaquone was administered before inoculation of 106Babesia microti and continued for 8 days thereafter, 9 of 10 hamsters survived beyond 54 days, but all untreated controls died within 12 days after inoculation. Quantitation of parasitemia showed a mean of 75% erythrocytes parasitized by day 5 in controls, but atovaquone recipients never exceeded 0.7% of parasitized erythrocytes over 54 days of observation. Clindamycin plus quinine was also effective but less so than atovaquone. When treatment was not started until parasitemia became established, atovaquone in doses of 300, 150, and 80 mglkglday was effective in the recovery of all animals compared with 50% of those receiving 10mg/kg/day and 10% of untreated controls. With its remarkable safety record, atovaquone offers promise for clinical trials in babesiosis of both humans and lower animals.

Original languageEnglish (US)
Pages (from-to)1042-1046
Number of pages5
JournalJournal of Infectious Diseases
Volume172
Issue number4
DOIs
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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