Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer

Karijn P.M. Suijkerbuijk, Elsken Van Der Wall, Helen Meijrink, Xiaojuan Pan, Inne H.M.Borel Rinkes, Margreet G.E.M. Ausems, Paul J. Van Diest

Research output: Contribution to journalArticle

Abstract

The high rate of interval malignancies urges for new screening methods for women at high risk for breast cancer. Nipple aspiration provides direct access to the breast tissue and its DNA, and therefore is a likely candidate, but clinical applications have been limited by the failure to obtain nipple aspiration fluid from most women. We performed oxytocin-assisted nipple aspiration in 90 women at increased risk for breast cancer based on family history or genetic test results (n = 63) and/or previous breast cancer (n = 34). Nipple fluid was obtained from 81/90 women (90%) and bilaterally in 77%. Mean discomfort rating was 0.6 (on a 0-10 scale), which was significantly lower than for mammography or MRI. These findings suggest that a new tool for biomarker detection in oxytocin-assisted nipple fluid of women at high risk for breast cancer is at hand.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalFamilial Cancer
Volume9
Issue number3
DOIs
StatePublished - Sep 1 2010

Keywords

  • BRCA1
  • BRCA2
  • Breast cancer
  • Early detection
  • Nipple aspiration
  • Screening

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Genetics(clinical)
  • Cancer Research

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  • Cite this

    Suijkerbuijk, K. P. M., Van Der Wall, E., Meijrink, H., Pan, X., Rinkes, I. H. M. B., Ausems, M. G. E. M., & Van Diest, P. J. (2010). Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer. Familial Cancer, 9(3), 321-325. https://doi.org/10.1007/s10689-010-9344-7