Successful immunization of infants at 6 months of age with high dose edmonston-zagreb measles vaccine

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Abstract

A group of 2097 Haitian infants 6 to 11 months of age were randomized to receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- to 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions were noted. Edmonston-Zagreb vaccines were more effective than equivalent doses of Schwarz vaccines as measured by the proportion of vaccinated children with measles antibody concentrations ≥200 mIU/ml 2 months after vaccination and the persistence of antibody at 18 to 24 months of age. High titer Edmonston-Zagreb vaccine administered at 6 months of age induced antibody concentrations ≥200 mIU/ml in 83% of infants by plaque reduction neutralization and 93% of infants by enzyme-linked immunosor-bent assay with high rates of antibody persistence at 12 to 24 months of age. The World Health Organization recommends high titer Edmonston-Zagreb measles vaccines for routine use at 6 months of age in areas where measles is an important cause of mortality in young infants.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalPediatric Infectious Disease Journal
Volume10
Issue number4
StatePublished - Apr 1991

Keywords

  • Immunization, developing countries
  • Maternai antibodies
  • Measles
  • Measles vaccine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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