Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

Rolla F. Abu-Arja; Leah R. Chernin; Ghada Abusin; Jeffery Auletta; Linda Cabral; Rachel Egler; Hans D. Ochs; Troy R. Torgerson; Jesus Lopez-Guisa; Robert W. Hostoffer; Haig Tcheurekdjian; Kenneth R. Cooke

doi:10.1002/pbc.25554

Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

Rolla F. Abu-Arja, Leah R. Chernin, Ghada Abusin, Jeffery Auletta, Linda Cabral, Rachel Egler, Hans D. Ochs, Troy R. Torgerson, Jesus Lopez-Guisa, Robert W. Hostoffer, Haig Tcheurekdjian, Kenneth R. Cooke

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19⁺ B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676.

Original language	English (US)
Pages (from-to)	1674-1676
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	62
Issue number	9
DOIs	https://doi.org/10.1002/pbc.25554
State	Published - Sep 1 2015

Keywords

Acute myeloid leukemia
Stem cell transplantation
X-linked agammaglobulinemia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Abu-Arja, R. F., Chernin, L. R., Abusin, G., Auletta, J., Cabral, L., Egler, R., Ochs, H. D., Torgerson, T. R., Lopez-Guisa, J., Hostoffer, R. W., Tcheurekdjian, H., & Cooke, K. R. (2015). Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia. Pediatric Blood and Cancer, 62(9), 1674-1676. https://doi.org/10.1002/pbc.25554

Abu-Arja, RF, Chernin, LR, Abusin, G, Auletta, J, Cabral, L, Egler, R, Ochs, HD, Torgerson, TR, Lopez-Guisa, J, Hostoffer, RW, Tcheurekdjian, H & Cooke, KR 2015, 'Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia', Pediatric Blood and Cancer, vol. 62, no. 9, pp. 1674-1676. https://doi.org/10.1002/pbc.25554

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abstract = "X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19+ B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676.",

keywords = "Acute myeloid leukemia, Stem cell transplantation, X-linked agammaglobulinemia",

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AU - Abu-Arja, Rolla F.

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AU - Auletta, Jeffery

AU - Cabral, Linda

AU - Egler, Rachel

AU - Ochs, Hans D.

AU - Torgerson, Troy R.

AU - Lopez-Guisa, Jesus

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AU - Tcheurekdjian, Haig

AU - Cooke, Kenneth R.

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AB - X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19+ B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676.

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Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

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Keywords

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