Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

Rolla F. Abu-Arja, Leah R. Chernin, Ghada Abusin, Jeffery Auletta, Linda Cabral, Rachel Egler, Hans D. Ochs, Troy R. Torgerson, Jesus Lopez-Guisa, Robert W. Hostoffer, Haig Tcheurekdjian, Kenneth R. Cooke

Research output: Contribution to journalArticlepeer-review

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19+ B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676.

Original languageEnglish (US)
Pages (from-to)1674-1676
Number of pages3
JournalPediatric Blood and Cancer
Volume62
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • Acute myeloid leukemia
  • Stem cell transplantation
  • X-linked agammaglobulinemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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