Successful growth of fresh retinoblastoma cells in chorioallantoic membrane

Silvia L. Fialho, Bárbara R. Silvestrini, Juliana Vieira, Mayara R.B. Paiva, Luciana M. Silva, Fernando Chahud, Armando Silva-Cunha, Zelia M. Correa, Rodrigo Jorge

Research output: Contribution to journalArticlepeer-review

Abstract

The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease.

Original languageEnglish (US)
Article number33
JournalInternational Journal of Retina and Vitreous
Volume6
Issue number1
DOIs
StatePublished - Jul 29 2020

Keywords

  • CAM assay
  • Chorioallantoic membrane
  • Retinoblastoma
  • Tumor models

ASJC Scopus subject areas

  • Ophthalmology

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