Successful endovascular management of massive pansinus thrombosis: Case report and review of literature

Alexander Drofa, Evgueni Kouznetsov, Stephen Tomek, Matthew Wiisanen, Michael Manchak, Timothy Lindley, Steven Mitchell, Ferdinand Hui, Dane Breker

Research output: Contribution to journalArticle

Abstract

Cerebral sinus venous thrombosis (CSVT) is a recognized cause of childhood and neonatal stroke. More than 50% of neonates have a poor outcome, and mortality is high. Coma is a predictor of death in neonatal CSVT. We present the case of a 9-day-old infant, who presented in coma and was treated successfully with a combination of mechanical thrombectomy using the MindFrame System via the right jugular vein, local infusion of recombinant tissue plasminogen activator and abciximab, as well as anticoagulation. In this case, aggressive thrombectomy and thrombolysis achieved complete neurologic restoration safely and quickly.

Original languageEnglish (US)
Pages (from-to)318-324
Number of pages7
JournalPediatric Neurosurgery
Volume51
Issue number6
DOIs
StatePublished - Oct 1 2016

Keywords

  • Abciximab
  • Endovascular thrombolysis
  • Newborn
  • Sinus thrombosis
  • Technique
  • Thrombectomy
  • Thrombolysis
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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  • Cite this

    Drofa, A., Kouznetsov, E., Tomek, S., Wiisanen, M., Manchak, M., Lindley, T., Mitchell, S., Hui, F., & Breker, D. (2016). Successful endovascular management of massive pansinus thrombosis: Case report and review of literature. Pediatric Neurosurgery, 51(6), 318-324. https://doi.org/10.1159/000447411