Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles

Fernando P. Polack, Sok H. Lee, Sallie Permar, Elizabeth Manyara, Hossein G. Nousari, Yaikah Jeng, Farah Mustafa, Alexandra Valsamakis, Robert J. Adams, Harriet L. Robinson, Diane E. Griffin

Research output: Contribution to journalArticle

Abstract

Measles remains a principal cause of worldwide mortality, in part because young infants cannot be immunized effectively. Development of new vaccines has been hindered by previous experience with a formalin-inactivated vaccine that predisposed to a severe form of disease (atypical measles). Here we have developed and tested potential DNA vaccines for immunogenicity, efficacy and safety in a rhesus macaque model of measles. DNA protected from challenge with wild-type measles virus. Protection correlated with levels of neutralizing antibody and not with cytotoxic T lymphocyte activity. There was no evidence in any group, including those receiving hemagglutinin-encoding DNA alone, of 'priming' for atypical measles.

Original languageEnglish (US)
Pages (from-to)776-781
Number of pages6
JournalNature medicine
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2000

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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