Success rate versus defibrillation energy: temporal profile and the most efficient defibrillation threshold

Yuji Murakawa, Bradford E. Gliner, Nitish V. Thakor

Research output: Contribution to journalArticlepeer-review


To determine the temporal profile of the energy requirement for defibrillation, shocks were delivered to canine hearts after 5, 10, or 20 seconds from the onset of fibrillation with a combination of patch and catheter electrodes. A total of 956 fibrillation-defibrillation sequences were performed at one of four energy levels appropriately selected for each period of fibrillation in 10 anesthetized dogs. The energy values related to 50% (E50) and 80% (E80) of the predicted success were calculated from a logistic regression curve. The E50 and E80 values at 10 seconds after the onset of fibrillation were less than those at 20 seconds after the onset by 7.1% ± 18.3% and 9.7% ± 21.4%, respectively; differences were not significant. At 5 seconds after the onset, the differences were 15.3% ± 14.2% (p < 0.02) and 16.4% ± 12.7% (p < 0.01), respectively. The defibrillation energy efficiency was assessed by dividing the success rate (SR) of fibrilation by the applied energy (E). The maximal SR E at 5, 10, and 20 seconds of fibrillation was achieved at the energy corresponding to the SRs of 88.8% ± 4.5%, 90.4% ± 3.9%, and 88.1% ± 4.6%, respectively. We conclude that the energy requirement for defibrillation increases with the duration of fibrillation, even shortly after the onset of fibrillation, and the maximal energy efficiency is attained at the energy associated with the SR of approximately 90%.

Original languageEnglish (US)
Pages (from-to)451-458
Number of pages8
JournalAmerican heart journal
Issue number3
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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