TY - JOUR
T1 - Subunit architecture of the golgi dsc e3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast
AU - Lloyd, S. Julie Ann
AU - Raychaudhuri, Sumana
AU - Espenshade, Peter J.
PY - 2013/7/19
Y1 - 2013/7/19
N2 - Background: Fungal sterol regulatory element-binding protein cleavage requires the Golgi Dsc E3 ligase complex of undefined structure. Results: Biochemical and bioinformatic analyses provide insight into Dsc E3 ligase architecture, indicating that Dsc2 is a ubiquitin-binding rhomboid pseudoprotease. Conclusion: The five Dsc E3 ligase subunits form subcomplexes and display defined connectivity. Significance: Multisubunit E3 ligase complexes in the ER and Golgi exhibit conserved subunit organization.
AB - Background: Fungal sterol regulatory element-binding protein cleavage requires the Golgi Dsc E3 ligase complex of undefined structure. Results: Biochemical and bioinformatic analyses provide insight into Dsc E3 ligase architecture, indicating that Dsc2 is a ubiquitin-binding rhomboid pseudoprotease. Conclusion: The five Dsc E3 ligase subunits form subcomplexes and display defined connectivity. Significance: Multisubunit E3 ligase complexes in the ER and Golgi exhibit conserved subunit organization.
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U2 - 10.1074/jbc.M113.468215
DO - 10.1074/jbc.M113.468215
M3 - Article
C2 - 23760507
AN - SCOPUS:84880519236
SN - 0021-9258
VL - 288
SP - 21043
EP - 21054
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 29
ER -