Subunit architecture of the golgi dsc e3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast

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Background: Fungal sterol regulatory element-binding protein cleavage requires the Golgi Dsc E3 ligase complex of undefined structure. Results: Biochemical and bioinformatic analyses provide insight into Dsc E3 ligase architecture, indicating that Dsc2 is a ubiquitin-binding rhomboid pseudoprotease. Conclusion: The five Dsc E3 ligase subunits form subcomplexes and display defined connectivity. Significance: Multisubunit E3 ligase complexes in the ER and Golgi exhibit conserved subunit organization.

Original languageEnglish (US)
Pages (from-to)21043-21054
Number of pages12
JournalJournal of Biological Chemistry
Issue number29
StatePublished - Jul 19 2013


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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