Subtyping schizophrenia: A comparison of positive/negative and system-specific approaches

F. U. Lang, S. Walther, K. Stegmayer, H. Anderson-Schmidt, T. G. Schulze, T. Becker, M. Jäger

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background Schizophrenia is a heterogeneous disorder. Over the years, different approaches have been proposed to approach this heterogeneity by categorizing symptom patterns. The study aimed to compare positive/negative and system-specific approaches to subtyping. Methods We used the Positive and Negative Syndrome Scale (PANSS) and Bern Psychopathology Scale (BPS), which consists of subscales for three domains (language, affect and motor behavior) that are hypothesized to be related to specific brain circuits, to assess cross-sectional psychopathological characteristics in a sample of 100 inpatients with schizophrenia spectrum disorders. We then categorized participants into positive/negative and system-specific subgroups to allow comparisons of the two approaches. Results The analyses revealed correlations between the PANSS positive subscore and the BPS affective subscore (r =.446, p

Original languageEnglish (US)
Article number51526
Pages (from-to)115-121
Number of pages7
JournalComprehensive Psychiatry
StatePublished - Aug 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine(all)


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