TY - JOUR
T1 - Subthreshold membrane conductances enhance directional selectivity in vertebrate sensory neurons
AU - Chacron, Maurice J.
AU - Fortune, Eric S.
PY - 2010/7
Y1 - 2010/7
N2 - Directional selectivity, in which neurons respond preferentially to one "preferred" direction of movement over the opposite "null" direction, is a critical computation that is found in the central nervous systems of many animals. Such responses are generated using two mechanisms: spatiotemporal convergence via pathways that differ in the timing of information from different locations on the receptor array and the nonlinear integration of this information. Previous studies have showed that various mechanisms may act as nonlinear integrators by suppressing the response in the null direction. Here we show, through a combination of mathematical modeling and in vivo intracellular recordings, that subthreshold membrane conductances can act as a nonlinear integrator by increasing the response in the preferred direction of motion only, thereby enhancing the directional bias. Such subthreshold conductances are ubiquitous in the CNS and therefore may be used in a wide array of computations that involve the enhancement of an existing bias arising from differential spatiotemporal filtering.
AB - Directional selectivity, in which neurons respond preferentially to one "preferred" direction of movement over the opposite "null" direction, is a critical computation that is found in the central nervous systems of many animals. Such responses are generated using two mechanisms: spatiotemporal convergence via pathways that differ in the timing of information from different locations on the receptor array and the nonlinear integration of this information. Previous studies have showed that various mechanisms may act as nonlinear integrators by suppressing the response in the null direction. Here we show, through a combination of mathematical modeling and in vivo intracellular recordings, that subthreshold membrane conductances can act as a nonlinear integrator by increasing the response in the preferred direction of motion only, thereby enhancing the directional bias. Such subthreshold conductances are ubiquitous in the CNS and therefore may be used in a wide array of computations that involve the enhancement of an existing bias arising from differential spatiotemporal filtering.
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U2 - 10.1152/jn.01113.2009
DO - 10.1152/jn.01113.2009
M3 - Article
C2 - 20445028
AN - SCOPUS:77954445314
SN - 0022-3077
VL - 104
SP - 449
EP - 462
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 1
ER -