Substance Use Disorders Are Independently Associated with Hospital Readmission Among Patients with Brain Tumors

Adrian E. Jimenez, Kyle V. Cicalese, Sachiv Chakravarti, Jose L. Porras, Tej D. Azad, Christopher M. Jackson, Gary Gallia, Chetan Bettegowda, Jon Weingart, Debraj Mukherjee

Research output: Contribution to journalArticlepeer-review


Background: Research on the effects of substance use disorders (SUDs) on postoperative outcomes within neurosurgical oncology has been limited. Therefore, the present study sought to quantify the effect of having a SUD on hospital length of stay, postoperative complication incidence, discharge disposition, hospital charges, 90-day readmission rates, and 90-day mortality rates following brain tumor surgery. Methods: The present study used data from patients who received surgical resection for brain tumor at a single institution between January 1, 2017, and December 31, 2019. The Mann–Whitney U test was used for bivariate analysis of continuous variables and Fisher exact test was used for bivariate analysis of categorical variables. Multivariate analysis was conducted using logistic regression models. Results: Our study cohort included a total of 2519 patients, 124 (4.9%) of whom had at least 1 SUD. More specifically, 90 (3.6%) patients had an alcohol use disorder, 27 (1.1%) had a cannabis use disorder, and 12 (0.5%) had an opioid use disorder. On bivariate analysis, 90-day hospital readmission was the only postoperative outcome significantly associated with a SUD (odds ratio 2.21, P = 0.0011). When controlling for patient age, sex, race, marital status, insurance, brain tumor diagnosis, 5-factor modified frailty index score, American Society of Anesthesiologists score, and surgery number, SUDs remained significantly and independently associated with 90-day readmission (odds ratio 1.82, P = 0.013). Conclusions: In patients with brain tumor, SUDs significantly and independently predict 90-day hospital readmission after surgery. Targeted management of patients with SUDs before and after surgery can optimize patient outcomes and improve the provision of high-value neurosurgical care.

Original languageEnglish (US)
Pages (from-to)e358-e368
JournalWorld neurosurgery
StatePublished - Oct 2022


  • Neuro-Oncology
  • Outcomes
  • Readmission
  • Substance use disorder

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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