Substance abuse, adherence with antiretroviral therapy, and clinical outcomes among HIV-infected individuals

Research output: Contribution to journalArticle

Abstract

Substance abuse and addiction are highly prevalent in HIV-infected individuals. Substance abuse is an important comorbidity that affects the delivery and outcomes of HIV medical management. In this paper I will review data examining the associations between substance abuse and HIV treatment and potential strategies to improve outcomes in this population that warrant further investigation. Current - but not past - substance abuse adversely affects engagement in care, acceptance of antiretroviral therapy, adherence with therapy, and long-term persistence in care. Substance abuse treatment appears to facilitate engagement in HIV care, and access to evidence-based treatment for substance abuse is central to addressing the HIV epidemic. Strategies that show promise for HIV-infected substance abusers include integrated treatment models, directly observed therapy, and incentive-based interventions.

Original languageEnglish (US)
Pages (from-to)948-952
Number of pages5
JournalLife Sciences
Volume88
Issue number21-22
DOIs
StatePublished - May 23 2011

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Substance-Related Disorders
HIV
Therapeutics
Directly Observed Therapy
Comorbidity
Motivation
Population

Keywords

  • Addiction
  • Adherence
  • HIV infection
  • Substance abuse

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Substance abuse, adherence with antiretroviral therapy, and clinical outcomes among HIV-infected individuals. / Lucas, Gregory M.

In: Life Sciences, Vol. 88, No. 21-22, 23.05.2011, p. 948-952.

Research output: Contribution to journalArticle

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