Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

Riccardo Sacconi, Robert F. Mullins, Gerard A. Lutty, Enrico Borrelli, Francesco Bandello, Giuseppe Querques

Research output: Contribution to journalArticle


Purpose: To report the presence of a new structural optical coherence tomography finding, namely, subretinal pseudocysts, in a patient affected by age-related macular degeneration. Methods: Case report including multimodal imaging discussion. Case Report: We report a case of a 77-year-old woman affected by age-related macular degeneration from 7 years. Best corrected visual acuity was counting fingers and 20/40 in the right and left eye, respectively. The left eye was affected by type 1 macular neovascularization treated by 34 intravitreal injections of anti-vascular endothelial growth factor (22 ranibizumab and 12 aflibercept injections). Interestingly, structural optical coherence tomography showed the persistence of a subretinal cystoid space (i.e. ‘subretinal pseudocyst’) after the last anti-vascular endothelial growth factor treatment, even in absence of other signs of exudation. Conclusions: Subretinal pseudocysts are a new structural optical coherence tomography entity. We reported for the first time the evidence that pseudocysts may develop in the subretinal space in a case of age-related macular degeneration.

Original languageEnglish (US)
Pages (from-to)NP24-NP26
JournalEuropean journal of ophthalmology
Issue number3
StatePublished - May 1 2020


  • Age-related macular degeneration
  • cystoid macular edema
  • optical coherence tomography
  • optical coherence tomography angiography
  • subretinal pseudocyst

ASJC Scopus subject areas

  • Ophthalmology

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