Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages

R. B. Zeidler, J. A. Flynn, J. C. Arnold, N. S. Conley

Research output: Contribution to journalArticle

Abstract

Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subpopulations generate superoxide anions, although to varying degrees. Band 3 cells are the most active, while band 1 cells are the least active. The amount of superoxide anions released in a mixed population of bands 1, 2, and 3 cells was less than the sum of that produced from each band assayed separately. Band 1 cells were found to inhibit by 47% the production of superoxide anions by band 3 cells. Conditioned medium from band 1 cells contains a heat-sensitive, nondialyzable, soluble factor responsible for this inhibition.

Original languageEnglish (US)
Pages (from-to)371-379
Number of pages9
JournalInflammation
Volume11
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

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Alveolar Macrophages
Superoxides
Macrophages
Population
Conditioned Culture Medium
Swine
Hot Temperature

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

Cite this

Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages. / Zeidler, R. B.; Flynn, J. A.; Arnold, J. C.; Conley, N. S.

In: Inflammation, Vol. 11, No. 3, 09.1987, p. 371-379.

Research output: Contribution to journalArticle

Zeidler, R. B. ; Flynn, J. A. ; Arnold, J. C. ; Conley, N. S. / Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages. In: Inflammation. 1987 ; Vol. 11, No. 3. pp. 371-379.
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