TY - JOUR
T1 - Subplate Neurons Regulate Maturation of Cortical Inhibition and Outcome of Ocular Dominance Plasticity
AU - Kanold, Patrick O.
AU - Shatz, Carla J.
N1 - Funding Information:
We thank M. Marcotrigiano, B. Printseva, and Y. Kim for surgical, histological, and technical assistance, and D. Butts, T. GrandPre, M. Majdan and J. Syken for comments on the manuscript. This work was supported by NIH ROI EY02858 (C.J.S.) and F32 EY1352 (P.O.K.).
PY - 2006/9/7
Y1 - 2006/9/7
N2 - Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involved in mature, fast GABAergic transmission in cortical layer 4, including GABA receptor subunits and KCC2, and thus prevents the switch to a hyperpolarizing effect of GABA. To understand the implications of these changes, a realistic circuit model was formulated. Simulations predicted that without subplate neurons, monocular deprivation (MD) paradoxically favors LGN axons representing the deprived (less active) eye, exactly what was then observed experimentally. Simulations also account for published results showing that OD plasticity requires mature inhibition. Thus, subplate neurons regulate molecular machinery required to establish an adult balance of excitation and inhibition in layer 4, and thereby influence the outcome of OD plasticity.
AB - Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involved in mature, fast GABAergic transmission in cortical layer 4, including GABA receptor subunits and KCC2, and thus prevents the switch to a hyperpolarizing effect of GABA. To understand the implications of these changes, a realistic circuit model was formulated. Simulations predicted that without subplate neurons, monocular deprivation (MD) paradoxically favors LGN axons representing the deprived (less active) eye, exactly what was then observed experimentally. Simulations also account for published results showing that OD plasticity requires mature inhibition. Thus, subplate neurons regulate molecular machinery required to establish an adult balance of excitation and inhibition in layer 4, and thereby influence the outcome of OD plasticity.
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=33748058836&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2006.07.008
DO - 10.1016/j.neuron.2006.07.008
M3 - Article
C2 - 16950160
AN - SCOPUS:33748058836
VL - 51
SP - 627
EP - 638
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -