Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: II. Quality of life outcomes. Submacular Surgery Trials Pilot Study report number 2

Neil M Bressler, Eric B Bass, Susan B Bressler, P. A. Campochiaro, J. A. Haller, A. P. Schachat, Barbara S Hawkins, T. Cain, M. Hartnett, P. Hawse, M. Herring, J. Impeach, J. McDonald, T. Porter, M. A. Thomas, N. M. Holekamp, T. A. Meredith, B. Barts, L. Breeding, J. DahlJ. L. Gualdoni, G. Hoffmeyer, V. Nobel, E. Ort, Jr Sternberg P., Jr Capone A., J. I. Lim, J. M. Brown, D. K. Gibbs, J. Gilman, J. Johnson, R. Swords, R. G. Waldron, G. A. Williams, B. R. Garretson, K. L. Cumming, T. Medina, B. Mitchell, V. Regan, P. Streasick, L. D. Szydlowski, M. Zajechowski, C. A. Toth, G. J. Jaffe, M. M. Anderson, T. J. Hawks, R. Heinis, R. Schirmer, L. J. Singerman, T. A. Rice, S. D. Pendergast, J. DuBois, M. A. Ilc, D. Knight, S. E. Lichterman, K. A. Tilocco, R. L. Bergren, A. Campbell, K. Sedory, D. Steinberg, G. Vagstad, L. Wellman, L. Wilcox, H. Lewis, J. Conway, L. J. Holody, P. J. Vargo, R. McDonald, R. N. Johnson, M. DiAngelo, I. Rozenfeld, J. Uy, S. Wild, P. Wood, M. Lambert, P. Miller, J. Shigley, A. J. Brucker, J. Dupont, J. Lurcott, L. Weeney, W. J. Wood, L. C. McDowell, M. Oldroyd, E. Slade, J. L. Wolfe, P. F. Lopez, T. Nichols, F. A. Walonker, W. R. Freeman, T. Clark, R. Ochabski, B. Ramirez, M. Wilson, M. E. Hammer, W. J. Malenfant, J. Rollins, J. Traynom, B. S. Hawkins, al et.

Research output: Contribution to journalArticle

Abstract

PURPOSE: To summarize findings from health-related quality-of-life interviews with patients who had recurrent subfoveal choroidal neovascularization secondary to age-related macular degeneration and participated in a randomized pilot trial (focal confluent laser photocoagulation versus submacular surgery) that may assist in planning future assessments of health-related quality of life in patients with age- related macular degeneration. PATIENTS AND METHODS: Of 70 patients enrolled in the pilot trial, 54 were interviewed before random assignment to treatment and provided the data analyzed for this report. Patients were scheduled for follow-up interviews at 6, 12, and 24 months after enrollment. The 36-Item Short-Form Health Survey was used in all cases and was administered by an interviewer. The summary scales, Physical Component Summary and Mental Component Summary, were the focus of this analysis. RESULTS: Median Physical Component Summary and Mental Component Summary score at baseline were 47 and 53, respectively. Distributions of scores at baseline and throughout the 2- year follow-up period were similar in the two treatment arms and consistent with those of a sample of the general US population of similar age. Distributions of both Physical Component Summary scores and Mental Component Summary scores for individual patient subgroups at baseline suggested sensitivity to some measures of baseline vision. During 2 years of follow-up interviews, median changes in Physical Component Summary scores were decreases of six points in the laser arm and three points in the surgery arm; in both treatment arms, median change in Mental Component Summary scores was an increase of 2 points. Two-year changes in visual acuity had no discernible effect on Physical Component Summary scores or Mental Component Summary scores; baseline scores were the strongest predictors of 2-year changes in Physical Component Summary and Mental Component Summary scores. CONCLUSIONS: Overall, summary scores from the 36-Item Short-Form Health Survey and changes in scores over 2 years in this pilot trial were consistent with the ophthalmic outcome measures (reported elsewhere) that showed no important differences between the treatment arms. These health-related quality-of-life findings provided assurance that the similarity of ophthalmic outcomes in the two treatment arms did not mask changes potentially important to patients that were not captured as part of the clinical outcome data. (C) 2000 by Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)408-418
Number of pages11
JournalAmerican Journal of Ophthalmology
Volume130
Issue number4
DOIs
StatePublished - Oct 2000

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Choroidal Neovascularization
Light Coagulation
Macular Degeneration
Lasers
Quality of Life
Interviews
Health Surveys
Therapeutics
Masks
Visual Acuity
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Ophthalmology

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Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration : II. Quality of life outcomes. Submacular Surgery Trials Pilot Study report number 2. / Bressler, Neil M; Bass, Eric B; Bressler, Susan B; Campochiaro, P. A.; Haller, J. A.; Schachat, A. P.; Hawkins, Barbara S; Cain, T.; Hartnett, M.; Hawse, P.; Herring, M.; Impeach, J.; McDonald, J.; Porter, T.; Thomas, M. A.; Holekamp, N. M.; Meredith, T. A.; Barts, B.; Breeding, L.; Dahl, J.; Gualdoni, J. L.; Hoffmeyer, G.; Nobel, V.; Ort, E.; Sternberg P., Jr; Capone A., Jr; Lim, J. I.; Brown, J. M.; Gibbs, D. K.; Gilman, J.; Johnson, J.; Swords, R.; Waldron, R. G.; Williams, G. A.; Garretson, B. R.; Cumming, K. L.; Medina, T.; Mitchell, B.; Regan, V.; Streasick, P.; Szydlowski, L. D.; Zajechowski, M.; Toth, C. A.; Jaffe, G. J.; Anderson, M. M.; Hawks, T. J.; Heinis, R.; Schirmer, R.; Singerman, L. J.; Rice, T. A.; Pendergast, S. D.; DuBois, J.; Ilc, M. A.; Knight, D.; Lichterman, S. E.; Tilocco, K. A.; Bergren, R. L.; Campbell, A.; Sedory, K.; Steinberg, D.; Vagstad, G.; Wellman, L.; Wilcox, L.; Lewis, H.; Conway, J.; Holody, L. J.; Vargo, P. J.; McDonald, R.; Johnson, R. N.; DiAngelo, M.; Rozenfeld, I.; Uy, J.; Wild, S.; Wood, P.; Lambert, M.; Miller, P.; Shigley, J.; Brucker, A. J.; Dupont, J.; Lurcott, J.; Weeney, L.; Wood, W. J.; McDowell, L. C.; Oldroyd, M.; Slade, E.; Wolfe, J. L.; Lopez, P. F.; Nichols, T.; Walonker, F. A.; Freeman, W. R.; Clark, T.; Ochabski, R.; Ramirez, B.; Wilson, M.; Hammer, M. E.; Malenfant, W. J.; Rollins, J.; Traynom, J.; Hawkins, B. S.; et., al.

In: American Journal of Ophthalmology, Vol. 130, No. 4, 10.2000, p. 408-418.

Research output: Contribution to journalArticle

Bressler, NM, Bass, EB, Bressler, SB, Campochiaro, PA, Haller, JA, Schachat, AP, Hawkins, BS, Cain, T, Hartnett, M, Hawse, P, Herring, M, Impeach, J, McDonald, J, Porter, T, Thomas, MA, Holekamp, NM, Meredith, TA, Barts, B, Breeding, L, Dahl, J, Gualdoni, JL, Hoffmeyer, G, Nobel, V, Ort, E, Sternberg P., J, Capone A., J, Lim, JI, Brown, JM, Gibbs, DK, Gilman, J, Johnson, J, Swords, R, Waldron, RG, Williams, GA, Garretson, BR, Cumming, KL, Medina, T, Mitchell, B, Regan, V, Streasick, P, Szydlowski, LD, Zajechowski, M, Toth, CA, Jaffe, GJ, Anderson, MM, Hawks, TJ, Heinis, R, Schirmer, R, Singerman, LJ, Rice, TA, Pendergast, SD, DuBois, J, Ilc, MA, Knight, D, Lichterman, SE, Tilocco, KA, Bergren, RL, Campbell, A, Sedory, K, Steinberg, D, Vagstad, G, Wellman, L, Wilcox, L, Lewis, H, Conway, J, Holody, LJ, Vargo, PJ, McDonald, R, Johnson, RN, DiAngelo, M, Rozenfeld, I, Uy, J, Wild, S, Wood, P, Lambert, M, Miller, P, Shigley, J, Brucker, AJ, Dupont, J, Lurcott, J, Weeney, L, Wood, WJ, McDowell, LC, Oldroyd, M, Slade, E, Wolfe, JL, Lopez, PF, Nichols, T, Walonker, FA, Freeman, WR, Clark, T, Ochabski, R, Ramirez, B, Wilson, M, Hammer, ME, Malenfant, WJ, Rollins, J, Traynom, J, Hawkins, BS & et., A 2000, 'Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: II. Quality of life outcomes. Submacular Surgery Trials Pilot Study report number 2', American Journal of Ophthalmology, vol. 130, no. 4, pp. 408-418. https://doi.org/10.1016/S0002-9394(00)00730-3
Bressler, Neil M ; Bass, Eric B ; Bressler, Susan B ; Campochiaro, P. A. ; Haller, J. A. ; Schachat, A. P. ; Hawkins, Barbara S ; Cain, T. ; Hartnett, M. ; Hawse, P. ; Herring, M. ; Impeach, J. ; McDonald, J. ; Porter, T. ; Thomas, M. A. ; Holekamp, N. M. ; Meredith, T. A. ; Barts, B. ; Breeding, L. ; Dahl, J. ; Gualdoni, J. L. ; Hoffmeyer, G. ; Nobel, V. ; Ort, E. ; Sternberg P., Jr ; Capone A., Jr ; Lim, J. I. ; Brown, J. M. ; Gibbs, D. K. ; Gilman, J. ; Johnson, J. ; Swords, R. ; Waldron, R. G. ; Williams, G. A. ; Garretson, B. R. ; Cumming, K. L. ; Medina, T. ; Mitchell, B. ; Regan, V. ; Streasick, P. ; Szydlowski, L. D. ; Zajechowski, M. ; Toth, C. A. ; Jaffe, G. J. ; Anderson, M. M. ; Hawks, T. J. ; Heinis, R. ; Schirmer, R. ; Singerman, L. J. ; Rice, T. A. ; Pendergast, S. D. ; DuBois, J. ; Ilc, M. A. ; Knight, D. ; Lichterman, S. E. ; Tilocco, K. A. ; Bergren, R. L. ; Campbell, A. ; Sedory, K. ; Steinberg, D. ; Vagstad, G. ; Wellman, L. ; Wilcox, L. ; Lewis, H. ; Conway, J. ; Holody, L. J. ; Vargo, P. J. ; McDonald, R. ; Johnson, R. N. ; DiAngelo, M. ; Rozenfeld, I. ; Uy, J. ; Wild, S. ; Wood, P. ; Lambert, M. ; Miller, P. ; Shigley, J. ; Brucker, A. J. ; Dupont, J. ; Lurcott, J. ; Weeney, L. ; Wood, W. J. ; McDowell, L. C. ; Oldroyd, M. ; Slade, E. ; Wolfe, J. L. ; Lopez, P. F. ; Nichols, T. ; Walonker, F. A. ; Freeman, W. R. ; Clark, T. ; Ochabski, R. ; Ramirez, B. ; Wilson, M. ; Hammer, M. E. ; Malenfant, W. J. ; Rollins, J. ; Traynom, J. ; Hawkins, B. S. ; et., al. / Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration : II. Quality of life outcomes. Submacular Surgery Trials Pilot Study report number 2. In: American Journal of Ophthalmology. 2000 ; Vol. 130, No. 4. pp. 408-418.
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abstract = "PURPOSE: To summarize findings from health-related quality-of-life interviews with patients who had recurrent subfoveal choroidal neovascularization secondary to age-related macular degeneration and participated in a randomized pilot trial (focal confluent laser photocoagulation versus submacular surgery) that may assist in planning future assessments of health-related quality of life in patients with age- related macular degeneration. PATIENTS AND METHODS: Of 70 patients enrolled in the pilot trial, 54 were interviewed before random assignment to treatment and provided the data analyzed for this report. Patients were scheduled for follow-up interviews at 6, 12, and 24 months after enrollment. The 36-Item Short-Form Health Survey was used in all cases and was administered by an interviewer. The summary scales, Physical Component Summary and Mental Component Summary, were the focus of this analysis. RESULTS: Median Physical Component Summary and Mental Component Summary score at baseline were 47 and 53, respectively. Distributions of scores at baseline and throughout the 2- year follow-up period were similar in the two treatment arms and consistent with those of a sample of the general US population of similar age. Distributions of both Physical Component Summary scores and Mental Component Summary scores for individual patient subgroups at baseline suggested sensitivity to some measures of baseline vision. During 2 years of follow-up interviews, median changes in Physical Component Summary scores were decreases of six points in the laser arm and three points in the surgery arm; in both treatment arms, median change in Mental Component Summary scores was an increase of 2 points. Two-year changes in visual acuity had no discernible effect on Physical Component Summary scores or Mental Component Summary scores; baseline scores were the strongest predictors of 2-year changes in Physical Component Summary and Mental Component Summary scores. CONCLUSIONS: Overall, summary scores from the 36-Item Short-Form Health Survey and changes in scores over 2 years in this pilot trial were consistent with the ophthalmic outcome measures (reported elsewhere) that showed no important differences between the treatment arms. These health-related quality-of-life findings provided assurance that the similarity of ophthalmic outcomes in the two treatment arms did not mask changes potentially important to patients that were not captured as part of the clinical outcome data. (C) 2000 by Elsevier Science Inc.",
author = "Bressler, {Neil M} and Bass, {Eric B} and Bressler, {Susan B} and Campochiaro, {P. A.} and Haller, {J. A.} and Schachat, {A. P.} and Hawkins, {Barbara S} and T. Cain and M. Hartnett and P. Hawse and M. Herring and J. Impeach and J. McDonald and T. Porter and Thomas, {M. A.} and Holekamp, {N. M.} and Meredith, {T. A.} and B. Barts and L. Breeding and J. Dahl and Gualdoni, {J. L.} and G. Hoffmeyer and V. Nobel and E. Ort and {Sternberg P.}, Jr and {Capone A.}, Jr and Lim, {J. I.} and Brown, {J. M.} and Gibbs, {D. K.} and J. Gilman and J. Johnson and R. Swords and Waldron, {R. G.} and Williams, {G. A.} and Garretson, {B. R.} and Cumming, {K. L.} and T. Medina and B. Mitchell and V. Regan and P. Streasick and Szydlowski, {L. D.} and M. Zajechowski and Toth, {C. A.} and Jaffe, {G. J.} and Anderson, {M. M.} and Hawks, {T. J.} and R. Heinis and R. Schirmer and Singerman, {L. J.} and Rice, {T. A.} and Pendergast, {S. D.} and J. DuBois and Ilc, {M. A.} and D. Knight and Lichterman, {S. E.} and Tilocco, {K. A.} and Bergren, {R. L.} and A. Campbell and K. Sedory and D. Steinberg and G. Vagstad and L. Wellman and L. Wilcox and H. Lewis and J. Conway and Holody, {L. J.} and Vargo, {P. J.} and R. McDonald and Johnson, {R. N.} and M. DiAngelo and I. Rozenfeld and J. Uy and S. Wild and P. Wood and M. Lambert and P. Miller and J. Shigley and Brucker, {A. J.} and J. Dupont and J. Lurcott and L. Weeney and Wood, {W. J.} and McDowell, {L. C.} and M. Oldroyd and E. Slade and Wolfe, {J. L.} and Lopez, {P. F.} and T. Nichols and Walonker, {F. A.} and Freeman, {W. R.} and T. Clark and R. Ochabski and B. Ramirez and M. Wilson and Hammer, {M. E.} and Malenfant, {W. J.} and J. Rollins and J. Traynom and Hawkins, {B. S.} and al et.",
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month = "10",
doi = "10.1016/S0002-9394(00)00730-3",
language = "English (US)",
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pages = "408--418",
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TY - JOUR

T1 - Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration

T2 - II. Quality of life outcomes. Submacular Surgery Trials Pilot Study report number 2

AU - Bressler, Neil M

AU - Bass, Eric B

AU - Bressler, Susan B

AU - Campochiaro, P. A.

AU - Haller, J. A.

AU - Schachat, A. P.

AU - Hawkins, Barbara S

AU - Cain, T.

AU - Hartnett, M.

AU - Hawse, P.

AU - Herring, M.

AU - Impeach, J.

AU - McDonald, J.

AU - Porter, T.

AU - Thomas, M. A.

AU - Holekamp, N. M.

AU - Meredith, T. A.

AU - Barts, B.

AU - Breeding, L.

AU - Dahl, J.

AU - Gualdoni, J. L.

AU - Hoffmeyer, G.

AU - Nobel, V.

AU - Ort, E.

AU - Sternberg P., Jr

AU - Capone A., Jr

AU - Lim, J. I.

AU - Brown, J. M.

AU - Gibbs, D. K.

AU - Gilman, J.

AU - Johnson, J.

AU - Swords, R.

AU - Waldron, R. G.

AU - Williams, G. A.

AU - Garretson, B. R.

AU - Cumming, K. L.

AU - Medina, T.

AU - Mitchell, B.

AU - Regan, V.

AU - Streasick, P.

AU - Szydlowski, L. D.

AU - Zajechowski, M.

AU - Toth, C. A.

AU - Jaffe, G. J.

AU - Anderson, M. M.

AU - Hawks, T. J.

AU - Heinis, R.

AU - Schirmer, R.

AU - Singerman, L. J.

AU - Rice, T. A.

AU - Pendergast, S. D.

AU - DuBois, J.

AU - Ilc, M. A.

AU - Knight, D.

AU - Lichterman, S. E.

AU - Tilocco, K. A.

AU - Bergren, R. L.

AU - Campbell, A.

AU - Sedory, K.

AU - Steinberg, D.

AU - Vagstad, G.

AU - Wellman, L.

AU - Wilcox, L.

AU - Lewis, H.

AU - Conway, J.

AU - Holody, L. J.

AU - Vargo, P. J.

AU - McDonald, R.

AU - Johnson, R. N.

AU - DiAngelo, M.

AU - Rozenfeld, I.

AU - Uy, J.

AU - Wild, S.

AU - Wood, P.

AU - Lambert, M.

AU - Miller, P.

AU - Shigley, J.

AU - Brucker, A. J.

AU - Dupont, J.

AU - Lurcott, J.

AU - Weeney, L.

AU - Wood, W. J.

AU - McDowell, L. C.

AU - Oldroyd, M.

AU - Slade, E.

AU - Wolfe, J. L.

AU - Lopez, P. F.

AU - Nichols, T.

AU - Walonker, F. A.

AU - Freeman, W. R.

AU - Clark, T.

AU - Ochabski, R.

AU - Ramirez, B.

AU - Wilson, M.

AU - Hammer, M. E.

AU - Malenfant, W. J.

AU - Rollins, J.

AU - Traynom, J.

AU - Hawkins, B. S.

AU - et., al

PY - 2000/10

Y1 - 2000/10

N2 - PURPOSE: To summarize findings from health-related quality-of-life interviews with patients who had recurrent subfoveal choroidal neovascularization secondary to age-related macular degeneration and participated in a randomized pilot trial (focal confluent laser photocoagulation versus submacular surgery) that may assist in planning future assessments of health-related quality of life in patients with age- related macular degeneration. PATIENTS AND METHODS: Of 70 patients enrolled in the pilot trial, 54 were interviewed before random assignment to treatment and provided the data analyzed for this report. Patients were scheduled for follow-up interviews at 6, 12, and 24 months after enrollment. The 36-Item Short-Form Health Survey was used in all cases and was administered by an interviewer. The summary scales, Physical Component Summary and Mental Component Summary, were the focus of this analysis. RESULTS: Median Physical Component Summary and Mental Component Summary score at baseline were 47 and 53, respectively. Distributions of scores at baseline and throughout the 2- year follow-up period were similar in the two treatment arms and consistent with those of a sample of the general US population of similar age. Distributions of both Physical Component Summary scores and Mental Component Summary scores for individual patient subgroups at baseline suggested sensitivity to some measures of baseline vision. During 2 years of follow-up interviews, median changes in Physical Component Summary scores were decreases of six points in the laser arm and three points in the surgery arm; in both treatment arms, median change in Mental Component Summary scores was an increase of 2 points. Two-year changes in visual acuity had no discernible effect on Physical Component Summary scores or Mental Component Summary scores; baseline scores were the strongest predictors of 2-year changes in Physical Component Summary and Mental Component Summary scores. CONCLUSIONS: Overall, summary scores from the 36-Item Short-Form Health Survey and changes in scores over 2 years in this pilot trial were consistent with the ophthalmic outcome measures (reported elsewhere) that showed no important differences between the treatment arms. These health-related quality-of-life findings provided assurance that the similarity of ophthalmic outcomes in the two treatment arms did not mask changes potentially important to patients that were not captured as part of the clinical outcome data. (C) 2000 by Elsevier Science Inc.

AB - PURPOSE: To summarize findings from health-related quality-of-life interviews with patients who had recurrent subfoveal choroidal neovascularization secondary to age-related macular degeneration and participated in a randomized pilot trial (focal confluent laser photocoagulation versus submacular surgery) that may assist in planning future assessments of health-related quality of life in patients with age- related macular degeneration. PATIENTS AND METHODS: Of 70 patients enrolled in the pilot trial, 54 were interviewed before random assignment to treatment and provided the data analyzed for this report. Patients were scheduled for follow-up interviews at 6, 12, and 24 months after enrollment. The 36-Item Short-Form Health Survey was used in all cases and was administered by an interviewer. The summary scales, Physical Component Summary and Mental Component Summary, were the focus of this analysis. RESULTS: Median Physical Component Summary and Mental Component Summary score at baseline were 47 and 53, respectively. Distributions of scores at baseline and throughout the 2- year follow-up period were similar in the two treatment arms and consistent with those of a sample of the general US population of similar age. Distributions of both Physical Component Summary scores and Mental Component Summary scores for individual patient subgroups at baseline suggested sensitivity to some measures of baseline vision. During 2 years of follow-up interviews, median changes in Physical Component Summary scores were decreases of six points in the laser arm and three points in the surgery arm; in both treatment arms, median change in Mental Component Summary scores was an increase of 2 points. Two-year changes in visual acuity had no discernible effect on Physical Component Summary scores or Mental Component Summary scores; baseline scores were the strongest predictors of 2-year changes in Physical Component Summary and Mental Component Summary scores. CONCLUSIONS: Overall, summary scores from the 36-Item Short-Form Health Survey and changes in scores over 2 years in this pilot trial were consistent with the ophthalmic outcome measures (reported elsewhere) that showed no important differences between the treatment arms. These health-related quality-of-life findings provided assurance that the similarity of ophthalmic outcomes in the two treatment arms did not mask changes potentially important to patients that were not captured as part of the clinical outcome data. (C) 2000 by Elsevier Science Inc.

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UR - http://www.scopus.com/inward/citedby.url?scp=0033802879&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(00)00730-3

DO - 10.1016/S0002-9394(00)00730-3

M3 - Article

C2 - 11024413

AN - SCOPUS:0033802879

VL - 130

SP - 408

EP - 418

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -