TY - JOUR
T1 - Sublingual vs oral immunotherapy for food allergy
T2 - Identifying the right approach
AU - Narisety, Satya D.
AU - Keet, Corinne A.
N1 - Funding Information:
This study was supported in part by a National Institutes of Health grant K23AI103187 to Corinne A. Keet. The authors have no conflicts of interest that are directly relevant to the content of this review.
PY - 2012
Y1 - 2012
N2 - The incidence of food allergy in developed countries has increased in recent years, escalating the need to find a suitable form of treatment as an alternative to current management, which includes strict avoidance and ready availability of injectable epinephrine (adrenaline). Allergen immunotherapy is currently being studied for use in the treatment of IgE-mediated food allergy to the most common foods, including peanut, tree nut, milk and egg. Two modalities, oral immunotherapy (OIT) and sublingual immunotherapy (SLIT), have shown great promise. Both OIT and SLIT have been able to desensitize subjects to varying degrees, but the two treatment methods differ in doses that can be achieved, duration of treatment, safety profile and ease of use outside the research setting, among other aspects. More research is needed to conclude which mode of treatment is more effective in inducing long-term tolerance with the least amount of serious adverse reactions. However, OIT and SLIT show great promise, and a widespread treatment for food allergy may be within reach.
AB - The incidence of food allergy in developed countries has increased in recent years, escalating the need to find a suitable form of treatment as an alternative to current management, which includes strict avoidance and ready availability of injectable epinephrine (adrenaline). Allergen immunotherapy is currently being studied for use in the treatment of IgE-mediated food allergy to the most common foods, including peanut, tree nut, milk and egg. Two modalities, oral immunotherapy (OIT) and sublingual immunotherapy (SLIT), have shown great promise. Both OIT and SLIT have been able to desensitize subjects to varying degrees, but the two treatment methods differ in doses that can be achieved, duration of treatment, safety profile and ease of use outside the research setting, among other aspects. More research is needed to conclude which mode of treatment is more effective in inducing long-term tolerance with the least amount of serious adverse reactions. However, OIT and SLIT show great promise, and a widespread treatment for food allergy may be within reach.
KW - Food-allergy-immunotherapies
KW - Food-hypersensitivity
KW - Oral
KW - Peanut-hypersensitivity
KW - Sublingual
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U2 - 10.2165/11640800-000000000-00000
DO - 10.2165/11640800-000000000-00000
M3 - Review article
C2 - 23009174
AN - SCOPUS:84867324865
SN - 0012-6667
VL - 72
SP - 1977
EP - 1989
JO - Drugs
JF - Drugs
IS - 15
ER -