Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation

W. C. Moore, J. D. Hasday, S. S. Meltzer, P. L. Wisnewski, B. White, E. R. Bleecker

Research output: Contribution to journalArticle

Abstract

Background: The relationship between severity of asthma and bronchial inflammation is poorly understood. Objective: We examined acute and subacute inflammatory responses to allergen in subjects with mild and moderate persistent asthma to evaluate whether different cellular and mediator responses to endobronchial allergen challenge are associated with differences in disease severity. Methods: Segmental allergen challenge was performed in 8 subjects with mild and 10 subjects with moderate allergic asthma to compare baseline airways inflammation and allergen-induced inflammatory responses 24 hours later. This evaluation was repeated after 6 weeks in 9 subjects to investigate the reproducibility of these inflammatory responses. Results: Subjects with mild and moderate asthma had similar decreases in FEV1 in response to segmental allergen challenge (9.1% ± 4.2% vs 15.1% ± 4.6%, P = .35). There was no difference in inflammatory cell counts or cytokine concentrations in the groups with mild and moderate asthma at baseline or after saline or allergen challenge. Repeat segmental allergen challenge 6 weeks later showed that these cellular and cytokine responses were reproducible. Conclusion: Segmental allergen challenge in subjects with mild and moderate asthma produces similar allergen-specific physiologic and inflammatory responses that are reproducible 6 weeks later. In this model of allergic asthma, acute responses to allergen do not appear to be related to disease severity.

Original languageEnglish (US)
Pages (from-to)908-914
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume108
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Allergens
Asthma
Inflammation
Bronchial Provocation Tests
Cytokines
Cell Count

Keywords

  • Asthma
  • Disease severity
  • Inflammation
  • Segmental allergen challenge

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation. / Moore, W. C.; Hasday, J. D.; Meltzer, S. S.; Wisnewski, P. L.; White, B.; Bleecker, E. R.

In: The Journal of Allergy and Clinical Immunology, Vol. 108, No. 6, 2001, p. 908-914.

Research output: Contribution to journalArticle

Moore, W. C. ; Hasday, J. D. ; Meltzer, S. S. ; Wisnewski, P. L. ; White, B. ; Bleecker, E. R. / Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation. In: The Journal of Allergy and Clinical Immunology. 2001 ; Vol. 108, No. 6. pp. 908-914.
@article{c634b03591cb4f4a8d07df6063f36ba0,
title = "Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation",
abstract = "Background: The relationship between severity of asthma and bronchial inflammation is poorly understood. Objective: We examined acute and subacute inflammatory responses to allergen in subjects with mild and moderate persistent asthma to evaluate whether different cellular and mediator responses to endobronchial allergen challenge are associated with differences in disease severity. Methods: Segmental allergen challenge was performed in 8 subjects with mild and 10 subjects with moderate allergic asthma to compare baseline airways inflammation and allergen-induced inflammatory responses 24 hours later. This evaluation was repeated after 6 weeks in 9 subjects to investigate the reproducibility of these inflammatory responses. Results: Subjects with mild and moderate asthma had similar decreases in FEV1 in response to segmental allergen challenge (9.1{\%} ± 4.2{\%} vs 15.1{\%} ± 4.6{\%}, P = .35). There was no difference in inflammatory cell counts or cytokine concentrations in the groups with mild and moderate asthma at baseline or after saline or allergen challenge. Repeat segmental allergen challenge 6 weeks later showed that these cellular and cytokine responses were reproducible. Conclusion: Segmental allergen challenge in subjects with mild and moderate asthma produces similar allergen-specific physiologic and inflammatory responses that are reproducible 6 weeks later. In this model of allergic asthma, acute responses to allergen do not appear to be related to disease severity.",
keywords = "Asthma, Disease severity, Inflammation, Segmental allergen challenge",
author = "Moore, {W. C.} and Hasday, {J. D.} and Meltzer, {S. S.} and Wisnewski, {P. L.} and B. White and Bleecker, {E. R.}",
year = "2001",
doi = "10.1067/mai.2001.119413",
language = "English (US)",
volume = "108",
pages = "908--914",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation

AU - Moore, W. C.

AU - Hasday, J. D.

AU - Meltzer, S. S.

AU - Wisnewski, P. L.

AU - White, B.

AU - Bleecker, E. R.

PY - 2001

Y1 - 2001

N2 - Background: The relationship between severity of asthma and bronchial inflammation is poorly understood. Objective: We examined acute and subacute inflammatory responses to allergen in subjects with mild and moderate persistent asthma to evaluate whether different cellular and mediator responses to endobronchial allergen challenge are associated with differences in disease severity. Methods: Segmental allergen challenge was performed in 8 subjects with mild and 10 subjects with moderate allergic asthma to compare baseline airways inflammation and allergen-induced inflammatory responses 24 hours later. This evaluation was repeated after 6 weeks in 9 subjects to investigate the reproducibility of these inflammatory responses. Results: Subjects with mild and moderate asthma had similar decreases in FEV1 in response to segmental allergen challenge (9.1% ± 4.2% vs 15.1% ± 4.6%, P = .35). There was no difference in inflammatory cell counts or cytokine concentrations in the groups with mild and moderate asthma at baseline or after saline or allergen challenge. Repeat segmental allergen challenge 6 weeks later showed that these cellular and cytokine responses were reproducible. Conclusion: Segmental allergen challenge in subjects with mild and moderate asthma produces similar allergen-specific physiologic and inflammatory responses that are reproducible 6 weeks later. In this model of allergic asthma, acute responses to allergen do not appear to be related to disease severity.

AB - Background: The relationship between severity of asthma and bronchial inflammation is poorly understood. Objective: We examined acute and subacute inflammatory responses to allergen in subjects with mild and moderate persistent asthma to evaluate whether different cellular and mediator responses to endobronchial allergen challenge are associated with differences in disease severity. Methods: Segmental allergen challenge was performed in 8 subjects with mild and 10 subjects with moderate allergic asthma to compare baseline airways inflammation and allergen-induced inflammatory responses 24 hours later. This evaluation was repeated after 6 weeks in 9 subjects to investigate the reproducibility of these inflammatory responses. Results: Subjects with mild and moderate asthma had similar decreases in FEV1 in response to segmental allergen challenge (9.1% ± 4.2% vs 15.1% ± 4.6%, P = .35). There was no difference in inflammatory cell counts or cytokine concentrations in the groups with mild and moderate asthma at baseline or after saline or allergen challenge. Repeat segmental allergen challenge 6 weeks later showed that these cellular and cytokine responses were reproducible. Conclusion: Segmental allergen challenge in subjects with mild and moderate asthma produces similar allergen-specific physiologic and inflammatory responses that are reproducible 6 weeks later. In this model of allergic asthma, acute responses to allergen do not appear to be related to disease severity.

KW - Asthma

KW - Disease severity

KW - Inflammation

KW - Segmental allergen challenge

UR - http://www.scopus.com/inward/record.url?scp=0035216096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035216096&partnerID=8YFLogxK

U2 - 10.1067/mai.2001.119413

DO - 10.1067/mai.2001.119413

M3 - Article

VL - 108

SP - 908

EP - 914

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 6

ER -