Subjective response to nicotine by menstrual phase

Alicia M. Allen, Scott Lunos, Stephen J. Heishman, Mustafa al'Absi, Dorothy Hatsukami, Sharon S. Allen

Research output: Contribution to journalArticle

Abstract

Introduction: The luteal menstrual phase might be a favorable time for smoking cessation when non-nicotine interventions (e.g. counseling, bupropion) are used, whereas the follicular menstrual phase appears favorable when nicotine interventions are used. Thus, there may be an interaction between menstrual phase and response to nicotine. We sought to examine the role of menstrual phase on response to nicotine during acute smoking abstinence. Methods: In this controlled cross-over trial, women completed two identical experimental sessions (follicular [F] vs. luteal [L] phase) after four days of biochemically-verified smoking abstinence. During the sessions, nicotine nasal spray was administered, and participants provided a series of subjective assessments. Results: Participants (n = 140) were 29.7 ± 6.6 years old and smoked 12.6 ± 5.8 cigarettes per day. Compared to the F phase, the L phase was associated with a greater increase in stimulation (7.2 ± 2.2 vs. 14.4 ± 2.3, p = 0.01, respectively) and greater decrease in urge to smoke (- 13.6 ± 2.3 vs - 21.1 ± 2.5, p = 0.02, respectively) after the first dose of nicotine. No other significant differences were observed. Conclusions: Out of 13 total measures examined at two different time points, we observed only two significant menstrual phase differences in the subjective response to nicotine. Therefore, these data do not provide strong evidence for a menstrual phase difference in the subjective response to nicotine. Additional research is needed to confirm this relationship and explore how non-nicotine smoking reinforcements (such as sensory sensations) may vary by menstrual phase.

Original languageEnglish (US)
Pages (from-to)50-53
Number of pages4
JournalAddictive Behaviors
Volume43
Issue number1
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Nicotine
Luteal Phase
Smoking
Tobacco Use Cessation Products
Bupropion
Follicular Phase
Smoking Cessation
Smoke
Tobacco Products
Cross-Over Studies
Counseling
Reinforcement
Research

Keywords

  • Addiction
  • Hormones
  • Menstrual cycle
  • Nicotine
  • Smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Toxicology
  • Medicine (miscellaneous)

Cite this

Allen, A. M., Lunos, S., Heishman, S. J., al'Absi, M., Hatsukami, D., & Allen, S. S. (2015). Subjective response to nicotine by menstrual phase. Addictive Behaviors, 43(1), 50-53. https://doi.org/10.1016/j.addbeh.2014.12.008

Subjective response to nicotine by menstrual phase. / Allen, Alicia M.; Lunos, Scott; Heishman, Stephen J.; al'Absi, Mustafa; Hatsukami, Dorothy; Allen, Sharon S.

In: Addictive Behaviors, Vol. 43, No. 1, 2015, p. 50-53.

Research output: Contribution to journalArticle

Allen, AM, Lunos, S, Heishman, SJ, al'Absi, M, Hatsukami, D & Allen, SS 2015, 'Subjective response to nicotine by menstrual phase', Addictive Behaviors, vol. 43, no. 1, pp. 50-53. https://doi.org/10.1016/j.addbeh.2014.12.008
Allen AM, Lunos S, Heishman SJ, al'Absi M, Hatsukami D, Allen SS. Subjective response to nicotine by menstrual phase. Addictive Behaviors. 2015;43(1):50-53. https://doi.org/10.1016/j.addbeh.2014.12.008
Allen, Alicia M. ; Lunos, Scott ; Heishman, Stephen J. ; al'Absi, Mustafa ; Hatsukami, Dorothy ; Allen, Sharon S. / Subjective response to nicotine by menstrual phase. In: Addictive Behaviors. 2015 ; Vol. 43, No. 1. pp. 50-53.
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N2 - Introduction: The luteal menstrual phase might be a favorable time for smoking cessation when non-nicotine interventions (e.g. counseling, bupropion) are used, whereas the follicular menstrual phase appears favorable when nicotine interventions are used. Thus, there may be an interaction between menstrual phase and response to nicotine. We sought to examine the role of menstrual phase on response to nicotine during acute smoking abstinence. Methods: In this controlled cross-over trial, women completed two identical experimental sessions (follicular [F] vs. luteal [L] phase) after four days of biochemically-verified smoking abstinence. During the sessions, nicotine nasal spray was administered, and participants provided a series of subjective assessments. Results: Participants (n = 140) were 29.7 ± 6.6 years old and smoked 12.6 ± 5.8 cigarettes per day. Compared to the F phase, the L phase was associated with a greater increase in stimulation (7.2 ± 2.2 vs. 14.4 ± 2.3, p = 0.01, respectively) and greater decrease in urge to smoke (- 13.6 ± 2.3 vs - 21.1 ± 2.5, p = 0.02, respectively) after the first dose of nicotine. No other significant differences were observed. Conclusions: Out of 13 total measures examined at two different time points, we observed only two significant menstrual phase differences in the subjective response to nicotine. Therefore, these data do not provide strong evidence for a menstrual phase difference in the subjective response to nicotine. Additional research is needed to confirm this relationship and explore how non-nicotine smoking reinforcements (such as sensory sensations) may vary by menstrual phase.

AB - Introduction: The luteal menstrual phase might be a favorable time for smoking cessation when non-nicotine interventions (e.g. counseling, bupropion) are used, whereas the follicular menstrual phase appears favorable when nicotine interventions are used. Thus, there may be an interaction between menstrual phase and response to nicotine. We sought to examine the role of menstrual phase on response to nicotine during acute smoking abstinence. Methods: In this controlled cross-over trial, women completed two identical experimental sessions (follicular [F] vs. luteal [L] phase) after four days of biochemically-verified smoking abstinence. During the sessions, nicotine nasal spray was administered, and participants provided a series of subjective assessments. Results: Participants (n = 140) were 29.7 ± 6.6 years old and smoked 12.6 ± 5.8 cigarettes per day. Compared to the F phase, the L phase was associated with a greater increase in stimulation (7.2 ± 2.2 vs. 14.4 ± 2.3, p = 0.01, respectively) and greater decrease in urge to smoke (- 13.6 ± 2.3 vs - 21.1 ± 2.5, p = 0.02, respectively) after the first dose of nicotine. No other significant differences were observed. Conclusions: Out of 13 total measures examined at two different time points, we observed only two significant menstrual phase differences in the subjective response to nicotine. Therefore, these data do not provide strong evidence for a menstrual phase difference in the subjective response to nicotine. Additional research is needed to confirm this relationship and explore how non-nicotine smoking reinforcements (such as sensory sensations) may vary by menstrual phase.

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