Subjective and objective screening tests for hydroxychloroquine toxicity

Catherine Cukras, Nancy Huynh, Susan Vitale, Wai T. Wong, Fredrick L. Ferris, Paul A. Sieving

Research output: Contribution to journalArticle

Abstract

Objective To compare subjective and objective clinical tests used in the screening for hydroxychloroquine retinal toxicity to multifocal electroretinography (mfERG) reference testing. Design Prospective, single-center, case control study. Participants Fifty-seven patients with a previous or current history of hydroxychloroquine treatment of more than 5 years' duration. Methods Participants were evaluated with a detailed medical history, dilated ophthalmologic examination, color fundus photography, fundus autofluorescence (FAF) imaging, spectral-domain (SD) optical coherence tomography (OCT), automated visual field testing (10-2 visual field mean deviation [VFMD]), and mfERG testing. We used mfERG test parameters as a gold standard to divide participants into 2 groups: those affected by hydroxychloroquine-induced retinal toxicity and those unaffected. Main Outcome Measures We assessed the association of various imaging and psychophysical variables in the affected versus the unaffected group. Results Fifty-seven study participants (91.2% female; mean age, 55.7±10.4 years; mean duration of hydroxychloroquine treatment, 15.0±7.5 years) were divided into affected (n = 19) and unaffected (n = 38) groups based on mfERG criteria. Mean age and duration of hydroxychloroquine treatment did not differ statistically between groups. Mean OCT retinal thickness measurements in all 9 macular subfields were significantly lower (

Original languageEnglish (US)
Pages (from-to)356-366
Number of pages11
JournalOphthalmology
Volume122
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Fingerprint

Hydroxychloroquine
Toxicity Tests
Electroretinography
Optical Coherence Tomography
Visual Fields
Photography
Optical Imaging
Case-Control Studies
Therapeutics
Color
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Cukras, C., Huynh, N., Vitale, S., Wong, W. T., Ferris, F. L., & Sieving, P. A. (2015). Subjective and objective screening tests for hydroxychloroquine toxicity. Ophthalmology, 122(2), 356-366. https://doi.org/10.1016/j.ophtha.2014.07.056

Subjective and objective screening tests for hydroxychloroquine toxicity. / Cukras, Catherine; Huynh, Nancy; Vitale, Susan; Wong, Wai T.; Ferris, Fredrick L.; Sieving, Paul A.

In: Ophthalmology, Vol. 122, No. 2, 01.02.2015, p. 356-366.

Research output: Contribution to journalArticle

Cukras, C, Huynh, N, Vitale, S, Wong, WT, Ferris, FL & Sieving, PA 2015, 'Subjective and objective screening tests for hydroxychloroquine toxicity', Ophthalmology, vol. 122, no. 2, pp. 356-366. https://doi.org/10.1016/j.ophtha.2014.07.056
Cukras C, Huynh N, Vitale S, Wong WT, Ferris FL, Sieving PA. Subjective and objective screening tests for hydroxychloroquine toxicity. Ophthalmology. 2015 Feb 1;122(2):356-366. https://doi.org/10.1016/j.ophtha.2014.07.056
Cukras, Catherine ; Huynh, Nancy ; Vitale, Susan ; Wong, Wai T. ; Ferris, Fredrick L. ; Sieving, Paul A. / Subjective and objective screening tests for hydroxychloroquine toxicity. In: Ophthalmology. 2015 ; Vol. 122, No. 2. pp. 356-366.
@article{4251a1ac56684c41a03de48365ac498c,
title = "Subjective and objective screening tests for hydroxychloroquine toxicity",
abstract = "Objective To compare subjective and objective clinical tests used in the screening for hydroxychloroquine retinal toxicity to multifocal electroretinography (mfERG) reference testing. Design Prospective, single-center, case control study. Participants Fifty-seven patients with a previous or current history of hydroxychloroquine treatment of more than 5 years' duration. Methods Participants were evaluated with a detailed medical history, dilated ophthalmologic examination, color fundus photography, fundus autofluorescence (FAF) imaging, spectral-domain (SD) optical coherence tomography (OCT), automated visual field testing (10-2 visual field mean deviation [VFMD]), and mfERG testing. We used mfERG test parameters as a gold standard to divide participants into 2 groups: those affected by hydroxychloroquine-induced retinal toxicity and those unaffected. Main Outcome Measures We assessed the association of various imaging and psychophysical variables in the affected versus the unaffected group. Results Fifty-seven study participants (91.2{\%} female; mean age, 55.7±10.4 years; mean duration of hydroxychloroquine treatment, 15.0±7.5 years) were divided into affected (n = 19) and unaffected (n = 38) groups based on mfERG criteria. Mean age and duration of hydroxychloroquine treatment did not differ statistically between groups. Mean OCT retinal thickness measurements in all 9 macular subfields were significantly lower (",
author = "Catherine Cukras and Nancy Huynh and Susan Vitale and Wong, {Wai T.} and Ferris, {Fredrick L.} and Sieving, {Paul A.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.ophtha.2014.07.056",
language = "English (US)",
volume = "122",
pages = "356--366",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Subjective and objective screening tests for hydroxychloroquine toxicity

AU - Cukras, Catherine

AU - Huynh, Nancy

AU - Vitale, Susan

AU - Wong, Wai T.

AU - Ferris, Fredrick L.

AU - Sieving, Paul A.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Objective To compare subjective and objective clinical tests used in the screening for hydroxychloroquine retinal toxicity to multifocal electroretinography (mfERG) reference testing. Design Prospective, single-center, case control study. Participants Fifty-seven patients with a previous or current history of hydroxychloroquine treatment of more than 5 years' duration. Methods Participants were evaluated with a detailed medical history, dilated ophthalmologic examination, color fundus photography, fundus autofluorescence (FAF) imaging, spectral-domain (SD) optical coherence tomography (OCT), automated visual field testing (10-2 visual field mean deviation [VFMD]), and mfERG testing. We used mfERG test parameters as a gold standard to divide participants into 2 groups: those affected by hydroxychloroquine-induced retinal toxicity and those unaffected. Main Outcome Measures We assessed the association of various imaging and psychophysical variables in the affected versus the unaffected group. Results Fifty-seven study participants (91.2% female; mean age, 55.7±10.4 years; mean duration of hydroxychloroquine treatment, 15.0±7.5 years) were divided into affected (n = 19) and unaffected (n = 38) groups based on mfERG criteria. Mean age and duration of hydroxychloroquine treatment did not differ statistically between groups. Mean OCT retinal thickness measurements in all 9 macular subfields were significantly lower (

AB - Objective To compare subjective and objective clinical tests used in the screening for hydroxychloroquine retinal toxicity to multifocal electroretinography (mfERG) reference testing. Design Prospective, single-center, case control study. Participants Fifty-seven patients with a previous or current history of hydroxychloroquine treatment of more than 5 years' duration. Methods Participants were evaluated with a detailed medical history, dilated ophthalmologic examination, color fundus photography, fundus autofluorescence (FAF) imaging, spectral-domain (SD) optical coherence tomography (OCT), automated visual field testing (10-2 visual field mean deviation [VFMD]), and mfERG testing. We used mfERG test parameters as a gold standard to divide participants into 2 groups: those affected by hydroxychloroquine-induced retinal toxicity and those unaffected. Main Outcome Measures We assessed the association of various imaging and psychophysical variables in the affected versus the unaffected group. Results Fifty-seven study participants (91.2% female; mean age, 55.7±10.4 years; mean duration of hydroxychloroquine treatment, 15.0±7.5 years) were divided into affected (n = 19) and unaffected (n = 38) groups based on mfERG criteria. Mean age and duration of hydroxychloroquine treatment did not differ statistically between groups. Mean OCT retinal thickness measurements in all 9 macular subfields were significantly lower (

UR - http://www.scopus.com/inward/record.url?scp=84921612326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921612326&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2014.07.056

DO - 10.1016/j.ophtha.2014.07.056

M3 - Article

C2 - 25444344

AN - SCOPUS:84921612326

VL - 122

SP - 356

EP - 366

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 2

ER -