Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers

Rebeca Soria, June M. Stapleton, Stephen F. Gilson, Angela Sampson-Cone, Jack E. Henningfield, Edythe D. London

Research output: Contribution to journalArticle

Abstract

The present study assessed the subjective and cardiovascular effects of intravenous nicotine in smokers and nonsmokers. Nonsmokers (n = 5) and smokers (n = 5) were administered a single dose of nicotine (0.75 or 1.5 mg) or saline on each of 3 days. The nicotine doses were given in ascending order in a double-blind fashion. Although smokers and nonsmokers manifested significant increases in systolic and diastolic blood pressure and heart rate 1 min after administration of all active test doses, the difference between peak heart rate and that measured at later times was greater in nonsmokers than in smokers. Nonsmokers and smokers also differed in subjective self-reports. In response to items on visual analogue scales indicative of positive effects (e.g., 'good effects', 'like drug', 'use again', and 'feel energetic'), smokers but not nonsmokers reported high scores (> 40) after nicotine injection. In addition, responses on the MBG and LSD subscales of the Addiction Research Center Inventory indicated that smokers experienced positive subjective effects after the test doses, whereas nonsmokers experienced disorientation. The fact that intravenous nicotine was not associated with positive subjective effects in nonsmokers indicates that repeated exposure is required to establish positive reinforcing effects of nicotine.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalPsychopharmacology
Volume128
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Nicotine
Heart Rate
Blood Pressure
Lysergic Acid Diethylamide
Visual Analog Scale
Self Report
Equipment and Supplies
Injections
Research
Pharmaceutical Preparations

Keywords

  • Cardiovascular responses
  • Nicotine
  • Non-smokers
  • Smokers
  • Subjective responses

ASJC Scopus subject areas

  • Pharmacology

Cite this

Soria, R., Stapleton, J. M., Gilson, S. F., Sampson-Cone, A., Henningfield, J. E., & London, E. D. (1996). Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers. Psychopharmacology, 128(3), 221-226. https://doi.org/10.1007/s002130050129

Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers. / Soria, Rebeca; Stapleton, June M.; Gilson, Stephen F.; Sampson-Cone, Angela; Henningfield, Jack E.; London, Edythe D.

In: Psychopharmacology, Vol. 128, No. 3, 1996, p. 221-226.

Research output: Contribution to journalArticle

Soria, R, Stapleton, JM, Gilson, SF, Sampson-Cone, A, Henningfield, JE & London, ED 1996, 'Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers', Psychopharmacology, vol. 128, no. 3, pp. 221-226. https://doi.org/10.1007/s002130050129
Soria R, Stapleton JM, Gilson SF, Sampson-Cone A, Henningfield JE, London ED. Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers. Psychopharmacology. 1996;128(3):221-226. https://doi.org/10.1007/s002130050129
Soria, Rebeca ; Stapleton, June M. ; Gilson, Stephen F. ; Sampson-Cone, Angela ; Henningfield, Jack E. ; London, Edythe D. / Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers. In: Psychopharmacology. 1996 ; Vol. 128, No. 3. pp. 221-226.
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