Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

Sydney E. Seidel; Barbara C. Tilley; Peng Huang; Yuko Y. Palesch; Kenneth J. Bergmann; Christopher G. Goetz; Christopher J. Swearingen

doi:10.1016/j.parkreldis.2011.10.006

Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

Sydney E. Seidel, Barbara C. Tilley, Peng Huang, Yuko Y. Palesch, Kenneth J. Bergmann, Christopher G. Goetz, Christopher J. Swearingen

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.

Original language	English (US)
Pages (from-to)	230-233
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.parkreldis.2011.10.006
State	Published - Mar 2012

Keywords

Concordance correlation
Kappa
NET-PD
Parkinson's disease
UPDRS

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2011.10.006

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title = "Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale",

abstract = "Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.",

keywords = "Concordance correlation, Kappa, NET-PD, Parkinson's disease, UPDRS",

author = "Seidel, {Sydney E.} and Tilley, {Barbara C.} and Peng Huang and Palesch, {Yuko Y.} and Bergmann, {Kenneth J.} and Goetz, {Christopher G.} and Swearingen, {Christopher J.}",

note = "Funding Information: Support for Ms. Seidel was received from NINDS T32 RR023258-01 . Dr. Swearingen received support from NINDS T32 NS48007-01A1 . Drs. Huang, Palesch, Goetz and Tilley received funding from NINDS U01NS043127 . Dr. Goetz is supported by the Parkinson{\textquoteright}s Disease Foundation (PDF) as part of the Rush PDF Parkinson{\textquoteright}s Disease Research Center. Dr. Bergmann received funding from NINDS U10-NS053372 . ",

year = "2012",

month = mar,

doi = "10.1016/j.parkreldis.2011.10.006",

language = "English (US)",

volume = "18",

pages = "230--233",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

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T1 - Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

AU - Seidel, Sydney E.

AU - Tilley, Barbara C.

AU - Huang, Peng

AU - Palesch, Yuko Y.

AU - Bergmann, Kenneth J.

AU - Goetz, Christopher G.

AU - Swearingen, Christopher J.

N1 - Funding Information: Support for Ms. Seidel was received from NINDS T32 RR023258-01 . Dr. Swearingen received support from NINDS T32 NS48007-01A1 . Drs. Huang, Palesch, Goetz and Tilley received funding from NINDS U01NS043127 . Dr. Goetz is supported by the Parkinson’s Disease Foundation (PDF) as part of the Rush PDF Parkinson’s Disease Research Center. Dr. Bergmann received funding from NINDS U10-NS053372 .

PY - 2012/3

Y1 - 2012/3

N2 - Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.

AB - Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.

KW - Concordance correlation

KW - Kappa

KW - NET-PD

KW - Parkinson's disease

KW - UPDRS

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Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

Abstract

Keywords

ASJC Scopus subject areas

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