Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

Sydney E. Seidel, Barbara C. Tilley, Peng Huang, Yuko Y. Palesch, Kenneth J. Bergmann, Christopher G. Goetz, Christopher J. Swearingen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalParkinsonism and Related Disorders
Volume18
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Concordance correlation
  • Kappa
  • NET-PD
  • Parkinson's disease
  • UPDRS

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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