Subcortical white matter abnormalities related to drug resistance in Wilson disease

D. Aikath; A. Gupta; I. Chattopadhyay; M. A. Hashmi; P. K. Gangopadhyay; S. K. Das; K. Ray

doi:10.1212/01.wnl.0000234130.27871.03

Subcortical white matter abnormalities related to drug resistance in Wilson disease

D. Aikath, A. Gupta, I. Chattopadhyay, M. A. Hashmi, P. K. Gangopadhyay, S. K. Das, K. Ray

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Wilson disease (WD) produces typical lesions in the brain, which can aid in diagnosis and therapy. The authors present a drug-resistant WD case with atypical cerebral lesions with marked involvement of white matter as visualized on MRI scans. The diagnosis was confirmed by identification of mutations in the ATP7B gene. The case demonstrates an uncommon pathology-related cerebral copper accumulation and emphasizes the importance of genetic screening in the diagnosis of WD.

Original language	English (US)
Pages (from-to)	878-880
Number of pages	3
Journal	Neurology
Volume	67
Issue number	5
DOIs	https://doi.org/10.1212/01.wnl.0000234130.27871.03
State	Published - Sep 2006
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "Subcortical white matter abnormalities related to drug resistance in Wilson disease",

abstract = "Wilson disease (WD) produces typical lesions in the brain, which can aid in diagnosis and therapy. The authors present a drug-resistant WD case with atypical cerebral lesions with marked involvement of white matter as visualized on MRI scans. The diagnosis was confirmed by identification of mutations in the ATP7B gene. The case demonstrates an uncommon pathology-related cerebral copper accumulation and emphasizes the importance of genetic screening in the diagnosis of WD.",

author = "D. Aikath and A. Gupta and I. Chattopadhyay and Hashmi, {M. A.} and Gangopadhyay, {P. K.} and Das, {S. K.} and K. Ray",

note = "Funding Information: Supported by a research grant (K.R.) and a fellowship (D.A.) from Indian Council of Medical Research (ICMR), Government of India. A.G. and I.C. are supported by fellowships from Council of Scientific and Industrial Research, India. ",

year = "2006",

month = sep,

doi = "10.1212/01.wnl.0000234130.27871.03",

language = "English (US)",

volume = "67",

pages = "878--880",

journal = "Neurology",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Subcortical white matter abnormalities related to drug resistance in Wilson disease

AU - Aikath, D.

AU - Gupta, A.

AU - Chattopadhyay, I.

AU - Hashmi, M. A.

AU - Gangopadhyay, P. K.

AU - Das, S. K.

AU - Ray, K.

N1 - Funding Information: Supported by a research grant (K.R.) and a fellowship (D.A.) from Indian Council of Medical Research (ICMR), Government of India. A.G. and I.C. are supported by fellowships from Council of Scientific and Industrial Research, India.

PY - 2006/9

Y1 - 2006/9

N2 - Wilson disease (WD) produces typical lesions in the brain, which can aid in diagnosis and therapy. The authors present a drug-resistant WD case with atypical cerebral lesions with marked involvement of white matter as visualized on MRI scans. The diagnosis was confirmed by identification of mutations in the ATP7B gene. The case demonstrates an uncommon pathology-related cerebral copper accumulation and emphasizes the importance of genetic screening in the diagnosis of WD.

AB - Wilson disease (WD) produces typical lesions in the brain, which can aid in diagnosis and therapy. The authors present a drug-resistant WD case with atypical cerebral lesions with marked involvement of white matter as visualized on MRI scans. The diagnosis was confirmed by identification of mutations in the ATP7B gene. The case demonstrates an uncommon pathology-related cerebral copper accumulation and emphasizes the importance of genetic screening in the diagnosis of WD.

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AN - SCOPUS:33748709871

SN - 0028-3878

VL - 67

SP - 878

EP - 880

JO - Neurology

JF - Neurology

IS - 5

ER -

Subcortical white matter abnormalities related to drug resistance in Wilson disease

Abstract

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