Abstract
Studies of cognitive functioning in patients with systemic lupus erythematosus (SLE) have found deficits even in patients without other evidence of neurologic involvement. The present study used scores on the 11 items of the Mini-Mental State Exam (MMSE) to classify the cognitive impairment of 93 SLE patients as suggestive of ″cortical″ or ″subcortical″ dysfunction using a validated statistical algorithm. Ninety-five percent of patients were categorized as having ″subcortical″ deficits, and 5% were categorized as having ″cortical″ deficits. When the analysis was limited to only those with total MMSE scores ≤ 24, 81% were classified as ″subcortical″ and 19% as ″cortical″. These results suggest that SLE patients can have psychomotor and mental tracking deficits of a type seen in patients with subcortical brain disease, even in the absence of gross neurologic involvement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 821-825 |
| Number of pages | 5 |
| Journal | Journal of the International Neuropsychological Society |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2000 |
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Keywords
- Cognitive impairment
- Subcortical brain disease
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Psychiatry and Mental health
- Neuroscience(all)
- Psychology(all)
Cite this
″Subcortical″ cognitive impairment in patients with systemic lupus erythematosus. / Leritz, Elizabeth; Brandt, Jason; Minor, Melissa; Reis-Jensen, Frances; Petri, Michelle.
In: Journal of the International Neuropsychological Society, Vol. 6, No. 7, 2000, p. 821-825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ″Subcortical″ cognitive impairment in patients with systemic lupus erythematosus
AU - Leritz, Elizabeth
AU - Brandt, Jason
AU - Minor, Melissa
AU - Reis-Jensen, Frances
AU - Petri, Michelle
PY - 2000
Y1 - 2000
N2 - Studies of cognitive functioning in patients with systemic lupus erythematosus (SLE) have found deficits even in patients without other evidence of neurologic involvement. The present study used scores on the 11 items of the Mini-Mental State Exam (MMSE) to classify the cognitive impairment of 93 SLE patients as suggestive of ″cortical″ or ″subcortical″ dysfunction using a validated statistical algorithm. Ninety-five percent of patients were categorized as having ″subcortical″ deficits, and 5% were categorized as having ″cortical″ deficits. When the analysis was limited to only those with total MMSE scores ≤ 24, 81% were classified as ″subcortical″ and 19% as ″cortical″. These results suggest that SLE patients can have psychomotor and mental tracking deficits of a type seen in patients with subcortical brain disease, even in the absence of gross neurologic involvement.
AB - Studies of cognitive functioning in patients with systemic lupus erythematosus (SLE) have found deficits even in patients without other evidence of neurologic involvement. The present study used scores on the 11 items of the Mini-Mental State Exam (MMSE) to classify the cognitive impairment of 93 SLE patients as suggestive of ″cortical″ or ″subcortical″ dysfunction using a validated statistical algorithm. Ninety-five percent of patients were categorized as having ″subcortical″ deficits, and 5% were categorized as having ″cortical″ deficits. When the analysis was limited to only those with total MMSE scores ≤ 24, 81% were classified as ″subcortical″ and 19% as ″cortical″. These results suggest that SLE patients can have psychomotor and mental tracking deficits of a type seen in patients with subcortical brain disease, even in the absence of gross neurologic involvement.
KW - Cognitive impairment
KW - Subcortical brain disease
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=0033625823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033625823&partnerID=8YFLogxK
U2 - 10.1017/S1355617700677093
DO - 10.1017/S1355617700677093
M3 - Article
C2 - 11105472
AN - SCOPUS:0033625823
VL - 6
SP - 821
EP - 825
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
SN - 1355-6177
IS - 7
ER -