Subclinical tuberculosis and adverse infant outcomes in pregnant women with HIV

Tshepiso Study Team

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Tuberculosis (TB) in pregnant women with HIV is associated with adverse maternal and infant outcomes. Previous studies have described a substantial prevalence of subclinical TB in this group, but little is known about the impact of subclinical TB on maternal and pediatric outcomes. METHODS: The Tshepiso Study recruited 235 HIVinfected pregnant women with TB (and matched HIV-positive, TB-negative pregnant controls), in Soweto, South Africa, from 2011 to 2014. During enrolment screening, some women initially recruited as controls were subsequently diagnosed with prevalent TB. We therefore assessed the prevalence of subclinical TB, associated participant characteristics and outcomes. RESULT S: Of 162 women initially recruited as TBnegative controls, seven (4.3%) were found to have TB on sputum culture. All seven had negative WHO symptom screens, and six (86%) were smear-negative. Of their seven infants, one was diagnosed with TB, and three (43%) experienced complications compared to zero infants with TB and 11% experiencing complications in the control group of TB-negative mothers (P= 0.045). CONCLUSION: We discovered an appreciable prevalence of subclinical TB in HIV-infected pregnant women in Soweto, which had not been detected by screening algorithms based solely on symptoms. Infants of HIVinfected mothers with subclinical TB appear to have a higher risk of adverse outcomes than those of TBnegative mothers.

Original languageEnglish (US)
Pages (from-to)681-685
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume24
Issue number7
DOIs
StatePublished - Jul 1 2020

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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