Subclinical thyroid dysfunction and fracture risk a meta-analysis

Manuel R. Blum, Douglas C. Bauer, Tinh Hai Collet, Howard A. Fink, Anne R. Cappola, Bruno R. Da Costa, Christina D. Wirth, Robin P. Peeters, Bjorn O. Asvold, Wendy P J Den Elzen, Robert N. Luben, Misa Imaizumi, Alexandra P. Bremner, Apostolos Gogakos, Richard Eastell, Patricia M. Kearney, Elsa S. Strotmeyer, Erin R. Wallace, Mari Hoff, Graziano Ceresini & 13 others Fernando Rivadeneira, Andre G. Uitterlinden, David J. Stott, Rudi G J Westendorp, Kay Tee Khaw, Arnuf Langhammer, Luigi Ferrucci, Jacobijn Gussekloo, Graham R. Williams, John P. Walsh, Peter Juni, Drahomir Aujesky, Nicolas Rodondi

Research output: Contribution to journalArticle

Abstract

IMPORTANCE Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking. OBJECTIVE To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures. DATA SOURCES AND STUDY SELECTION The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures. DATA EXTRACTION Individual participant datawere obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid functionwere defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH

Original languageEnglish (US)
Pages (from-to)2055-2065
Number of pages11
JournalJournal of the American Medical Association
Volume313
Issue number20
DOIs
StatePublished - May 26 2015
Externally publishedYes

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Meta-Analysis
Thyroid Gland
Thyrotropin
Information Storage and Retrieval
Hyperthyroidism
MEDLINE
Hip
Japan
Spine
Cohort Studies
Language
Clinical Trials
Databases
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blum, M. R., Bauer, D. C., Collet, T. H., Fink, H. A., Cappola, A. R., Da Costa, B. R., ... Rodondi, N. (2015). Subclinical thyroid dysfunction and fracture risk a meta-analysis. Journal of the American Medical Association, 313(20), 2055-2065. https://doi.org/10.1001/jama.2015.5161

Subclinical thyroid dysfunction and fracture risk a meta-analysis. / Blum, Manuel R.; Bauer, Douglas C.; Collet, Tinh Hai; Fink, Howard A.; Cappola, Anne R.; Da Costa, Bruno R.; Wirth, Christina D.; Peeters, Robin P.; Asvold, Bjorn O.; Den Elzen, Wendy P J; Luben, Robert N.; Imaizumi, Misa; Bremner, Alexandra P.; Gogakos, Apostolos; Eastell, Richard; Kearney, Patricia M.; Strotmeyer, Elsa S.; Wallace, Erin R.; Hoff, Mari; Ceresini, Graziano; Rivadeneira, Fernando; Uitterlinden, Andre G.; Stott, David J.; Westendorp, Rudi G J; Khaw, Kay Tee; Langhammer, Arnuf; Ferrucci, Luigi; Gussekloo, Jacobijn; Williams, Graham R.; Walsh, John P.; Juni, Peter; Aujesky, Drahomir; Rodondi, Nicolas.

In: Journal of the American Medical Association, Vol. 313, No. 20, 26.05.2015, p. 2055-2065.

Research output: Contribution to journalArticle

Blum, MR, Bauer, DC, Collet, TH, Fink, HA, Cappola, AR, Da Costa, BR, Wirth, CD, Peeters, RP, Asvold, BO, Den Elzen, WPJ, Luben, RN, Imaizumi, M, Bremner, AP, Gogakos, A, Eastell, R, Kearney, PM, Strotmeyer, ES, Wallace, ER, Hoff, M, Ceresini, G, Rivadeneira, F, Uitterlinden, AG, Stott, DJ, Westendorp, RGJ, Khaw, KT, Langhammer, A, Ferrucci, L, Gussekloo, J, Williams, GR, Walsh, JP, Juni, P, Aujesky, D & Rodondi, N 2015, 'Subclinical thyroid dysfunction and fracture risk a meta-analysis', Journal of the American Medical Association, vol. 313, no. 20, pp. 2055-2065. https://doi.org/10.1001/jama.2015.5161
Blum MR, Bauer DC, Collet TH, Fink HA, Cappola AR, Da Costa BR et al. Subclinical thyroid dysfunction and fracture risk a meta-analysis. Journal of the American Medical Association. 2015 May 26;313(20):2055-2065. https://doi.org/10.1001/jama.2015.5161
Blum, Manuel R. ; Bauer, Douglas C. ; Collet, Tinh Hai ; Fink, Howard A. ; Cappola, Anne R. ; Da Costa, Bruno R. ; Wirth, Christina D. ; Peeters, Robin P. ; Asvold, Bjorn O. ; Den Elzen, Wendy P J ; Luben, Robert N. ; Imaizumi, Misa ; Bremner, Alexandra P. ; Gogakos, Apostolos ; Eastell, Richard ; Kearney, Patricia M. ; Strotmeyer, Elsa S. ; Wallace, Erin R. ; Hoff, Mari ; Ceresini, Graziano ; Rivadeneira, Fernando ; Uitterlinden, Andre G. ; Stott, David J. ; Westendorp, Rudi G J ; Khaw, Kay Tee ; Langhammer, Arnuf ; Ferrucci, Luigi ; Gussekloo, Jacobijn ; Williams, Graham R. ; Walsh, John P. ; Juni, Peter ; Aujesky, Drahomir ; Rodondi, Nicolas. / Subclinical thyroid dysfunction and fracture risk a meta-analysis. In: Journal of the American Medical Association. 2015 ; Vol. 313, No. 20. pp. 2055-2065.
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AU - Langhammer, Arnuf

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