Subclinical thyroid dysfunction and fracture risk a meta-analysis

Manuel R. Blum; Douglas C. Bauer; Tinh Hai Collet; Howard A. Fink; Anne R. Cappola; Bruno R. Da Costa; Christina D. Wirth; Robin P. Peeters; Bjorn O. Asvold; Wendy P J Den Elzen; Robert N. Luben; Misa Imaizumi; Alexandra P. Bremner; Apostolos Gogakos; Richard Eastell; Patricia M. Kearney; Elsa S. Strotmeyer; Erin R. Wallace; Mari Hoff; Graziano Ceresini; Fernando Rivadeneira; Andre G. Uitterlinden; David J. Stott; Rudi G J Westendorp; Kay Tee Khaw; Arnuf Langhammer; Luigi Ferrucci; Jacobijn Gussekloo; Graham R. Williams; John P. Walsh; Peter Juni; Drahomir Aujesky; Nicolas Rodondi

doi:10.1001/jama.2015.5161

Subclinical thyroid dysfunction and fracture risk a meta-analysis

Manuel R. Blum, Douglas C. Bauer, Tinh Hai Collet, Howard A. Fink, Anne R. Cappola, Bruno R. Da Costa, Christina D. Wirth, Robin P. Peeters, Bjorn O. Asvold, Wendy P J Den Elzen, Robert N. Luben, Misa Imaizumi, Alexandra P. Bremner, Apostolos Gogakos, Richard Eastell, Patricia M. Kearney, Elsa S. Strotmeyer, Erin R. Wallace, Mari Hoff, Graziano CeresiniFernando Rivadeneira, Andre G. Uitterlinden, David J. Stott, Rudi G J Westendorp, Kay Tee Khaw, Arnuf Langhammer, Luigi Ferrucci, Jacobijn Gussekloo, Graham R. Williams, John P. Walsh, Peter Juni, Drahomir Aujesky, Nicolas Rodondi

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Abstract

IMPORTANCE Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking. OBJECTIVE To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures. DATA SOURCES AND STUDY SELECTION The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures. DATA EXTRACTION Individual participant datawere obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid functionwere defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH

Original language	English (US)
Pages (from-to)	2055-2065
Number of pages	11
Journal	Journal of the American Medical Association
Volume	313
Issue number	20
DOIs	https://doi.org/10.1001/jama.2015.5161
State	Published - May 26 2015
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Blum, M. R., Bauer, D. C., Collet, T. H., Fink, H. A., Cappola, A. R., Da Costa, B. R., Wirth, C. D., Peeters, R. P., Asvold, B. O., Den Elzen, W. P. J., Luben, R. N., Imaizumi, M., Bremner, A. P., Gogakos, A., Eastell, R., Kearney, P. M., Strotmeyer, E. S., Wallace, E. R., Hoff, M., ... Rodondi, N. (2015). Subclinical thyroid dysfunction and fracture risk a meta-analysis. Journal of the American Medical Association, 313(20), 2055-2065. https://doi.org/10.1001/jama.2015.5161

Blum, MR, Bauer, DC, Collet, TH, Fink, HA, Cappola, AR, Da Costa, BR, Wirth, CD, Peeters, RP, Asvold, BO, Den Elzen, WPJ, Luben, RN, Imaizumi, M, Bremner, AP, Gogakos, A, Eastell, R, Kearney, PM, Strotmeyer, ES, Wallace, ER, Hoff, M, Ceresini, G, Rivadeneira, F, Uitterlinden, AG, Stott, DJ, Westendorp, RGJ, Khaw, KT, Langhammer, A, Ferrucci, L, Gussekloo, J, Williams, GR, Walsh, JP, Juni, P, Aujesky, D & Rodondi, N 2015, 'Subclinical thyroid dysfunction and fracture risk a meta-analysis', Journal of the American Medical Association, vol. 313, no. 20, pp. 2055-2065. https://doi.org/10.1001/jama.2015.5161

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abstract = "IMPORTANCE Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking. OBJECTIVE To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures. DATA SOURCES AND STUDY SELECTION The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures. DATA EXTRACTION Individual participant datawere obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid functionwere defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH ",

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AU - Cappola, Anne R.

AU - Da Costa, Bruno R.

AU - Wirth, Christina D.

AU - Peeters, Robin P.

AU - Asvold, Bjorn O.

AU - Den Elzen, Wendy P J

AU - Luben, Robert N.

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AU - Bremner, Alexandra P.

AU - Gogakos, Apostolos

AU - Eastell, Richard

AU - Kearney, Patricia M.

AU - Strotmeyer, Elsa S.

AU - Wallace, Erin R.

AU - Hoff, Mari

AU - Ceresini, Graziano

AU - Rivadeneira, Fernando

AU - Uitterlinden, Andre G.

AU - Stott, David J.

AU - Westendorp, Rudi G J

AU - Khaw, Kay Tee

AU - Langhammer, Arnuf

AU - Ferrucci, Luigi

AU - Gussekloo, Jacobijn

AU - Williams, Graham R.

AU - Walsh, John P.

AU - Juni, Peter

AU - Aujesky, Drahomir

AU - Rodondi, Nicolas

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Subclinical thyroid dysfunction and fracture risk a meta-analysis

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